Cortical control of a whisking central pattern generator.

Journal of Neurophysiology
Nathan P Cramer, Asaf Keller

Abstract

Whether the motor cortex regulates voluntary movements by generating the motor pattern directly or by acting through subcortical central pattern generators (CPGs) remains a central question in motor control. Using the rat whisker system, an important model system of mammalian motor control, we develop an anesthetized preparation to investigate the interaction between the motor cortex and a whisking CPG. Using this model we investigate the involvement of a serotonergic component of the whisking CPG in determining whisking kinematics and the mechanisms through which drive from the CPG is converted into movements by vibrissa motor units. Consistent with an action of the vibrissa motor cortex (vMCx) on a subcortical CPG, the frequency of whisking evoked by intracortical microstimulation (ICMS) of vMCx differed significantly from the stimulation frequency, whereas whisking onset latencies correlated negatively with stimulation intensity. Further, ICMS-evoked whisking was suppressed by a serotonin receptor antagonist, supporting previous findings that the whisking CPG contains a significant serotonergic component. The amplitude of ICMS-evoked whisking was correlated with the number of active motor units-isolated from vibrissal EMGs o...Continue Reading

References

Jun 1, 1978·Electroencephalography and Clinical Neurophysiology·E J NeafseyN A Buchwald
Jan 1, 1991·Somatosensory & Motor Research·G E CarvellP Bryant
Dec 1, 1988·Brain Research. Developmental Brain Research·A IrikiY Nakamura
Feb 1, 1985·The Journal of Comparative Neurology·B G Klein, R W Rhoades
Aug 1, 1982·The Journal of Physiology·C J De LucaA P Xenakis
Jan 1, 1996·Somatosensory & Motor Research·G E CarvellD J Simons
Mar 1, 1997·Behavioural Brain Research·M BrechtM M Merzenich
Feb 18, 1998·Current Opinion in Neurobiology·Y I ArshavskyG N Orlovsky
Oct 9, 1998·Journal of Neuroscience Methods·R BermejoH P Zeigler
Jul 25, 2000·Trends in Neurosciences·A N Iwaniuk, I Q Whishaw
Jan 5, 2002·The Journal of Comparative Neurology·Alexis M HattoxAsaf Keller
Jun 14, 2002·Neuron·Michael S A GrazianoTirin Moore
Jul 23, 2003·Neuron·Alexis HattoxAsaf Keller
May 1, 1965·Journal of Neurophysiology·E HENNEMAND O CARPENTER
Dec 17, 2003·Somatosensory & Motor Research·Puhong GaoH Philip Zeigler
Aug 28, 2004·Journal of Neurophysiology·Kurt F Ahrens, David Kleinfeld
Feb 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Florent Haiss, Cornelius Schwarz
Sep 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Valery GrinevichPavel Osten
Oct 28, 2005·Journal of Neurophysiology·Wendy A FriedmanAsaf Keller

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Citations

Nov 18, 2008·Nature Neuroscience·SooHyun LeeDaniel J Simons
Apr 9, 2013·Nature Neuroscience·Knarik BagdasarianEhud Ahissar
Mar 3, 2007·Proceedings. Biological Sciences·Ben MitchinsonTony J Prescott
Mar 10, 2012·Journal of Neurophysiology·Jorge M MéndezFranz Goller
Oct 14, 2011·Journal of Neurophysiology·Wendy A FriedmanAsaf Keller
Jan 5, 2007·Journal of Neurophysiology·Nathan P CramerAsaf Keller
Feb 1, 2008·Journal of Neurophysiology·Radi MasriAsaf Keller
May 3, 2008·Journal of Neurophysiology·Shubhodeep ChakrabartiKevin D Alloway
Jun 20, 2008·Journal of Neurophysiology·Marie E Hemelt, Asaf Keller
May 14, 2014·Annual Review of Neuroscience·Carl C H Petersen
Apr 5, 2011·Annual Review of Neuroscience·Neeraj J Gandhi, Husam A Katnani
Dec 3, 2015·Trends in Cognitive Sciences·Michael S A Graziano
Dec 17, 2008·Trends in Neurosciences·Per Magne Knutsen, Ehud Ahissar
Jul 31, 2013·The European Journal of Neuroscience·Carlo VeronesiGianfranco Franchi
Jul 14, 2006·Current Opinion in Neurobiology·David KleinfeldMathew E Diamond
Dec 7, 2007·Neuron·Isabelle FerezouCarl C H Petersen
Sep 17, 2010·Journal of Neurophysiology·Maciej Dominik PietrZvi Vogel
Oct 24, 2014·Journal of Neurophysiology·Jakob VoigtsTansu Celikel
Sep 19, 2019·Journal of Neurophysiology·Omer TsurRony Azouz
Aug 19, 2017·Experimental Brain Research·Yoav GimmonMichael C Schubert
Sep 27, 2021·Neural Networks : the Official Journal of the International Neural Network Society·Francesco MannellaGiovanni Pezzulo

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