Cortical dysplasia: an immunocytochemical study of three patients

Neurology
Roberto SpreaficoM Avoli

Abstract

Human cortical dysplastic lesions are frequently associated with severe partial epilepsies. We report an immunocytochemical investigation on cortical tissue from three surgically treated patients, 20, 38, and 14 years old, with intractable epilepsy due to cortical dysplasia. The studies were performed using antibodies recognizing cytoskeletal proteins, calcium-binding proteins, and some subunits of glutamate receptors. The specimens from the three patients displayed common features: (1) focal cytoarchitectural abnormalities with an increased number of giant pyramidal neurons through all cortical layers except layer I; (2) large, round-shaped balloon cells mainly concentrated in the deepest part of the cortex and in the white matter; (3) a decrease of calcium binding protein immunopositive gamma-aminobutyric acid (GABA)ergic neurons; and (4) abnormal baskets of parvalbumin-positive terminals around the excitatory (pyramidal and large, round-shaped) neurons. These data provide evidence that the epileptogenicity in these types of cortical dysplasia is due to an increase in excitatory neurons coupled with a decrease in GABAergic interneurons.

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Citations

May 7, 2005·Acta Neuropathologica·Chris EnglundRobert F Hevner
Jun 21, 2005·Acta Neuropathologica·Michelle HildebrandtIngmar Blümcke
Jun 25, 2013·Acta Neuropathologica·Adele FinardiGiorgio Stefano Battaglia
Oct 9, 1999·Epilepsy Research·D R CotterI Everall
Oct 9, 1999·Epilepsy Research·K M JacobsD A Prince
Jan 5, 2002·Neurosurgery Clinics of North America·Richard A PraysonHarry V Vinters
Jun 17, 2003·Annals of Diagnostic Pathology·Richard A Prayson, John L Frater
Jul 10, 2003·Lancet Neurology·Giuliano Avanzini, Silvana Franceschetti
Jul 18, 2002·Epilepsia·Joo-Yong KimChun-Kee Chung
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Scott C BarabanArturo Alvarez-Buylla
May 9, 2009·Journal of Neurotrauma·Sinziana AvramescuIgor Timofeev
Mar 20, 2009·Brain : a Journal of Neurology·Julia JacobsJean Gotman
Jul 14, 1999·Epilepsia·N Chevassus-au-LouisY Ben-Ari
Jul 1, 1999·Epilepsia·G L HolmesN Chevassus-Au-Louis
Sep 22, 2000·Epilepsia·R SpreaficoC Munari
Apr 2, 2010·Epilepsia·Andre Palmini
Jul 31, 2012·International Journal of Hepatology·Rajakumar NagarajanM Albert Thomas
Feb 8, 2006·Neurosurgical Focus·Vincent Y WangNicholas M Barbaro
Jul 17, 2004·Journal of Neurosurgery·Aaron A Cohen-GadolDennis D Spencer
Jun 12, 2014·Acta Neuropathologica·Imad M NajmGiorgio Lo Russo
Feb 1, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Eleonora Aronica, Peter B Crino
Apr 29, 2008·Neuro-Chirurgie·P VarletC Daumas-Duport

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