Cortical dysplasia and epilepsy: animal models

Advances in Experimental Medicine and Biology
Philip A SchwartzkroinH Jurgen Wenzel

Abstract

Cortical dysplasia syndromes--those conditions of abnormal brain structure/organization that arise during aberrant brain development--frequently involve epileptic seizures. Neuropathological and neuroradiological analyses have provided descriptions and categorizations based on gross anatomical and cellular histological features (e.g., lissencephaly, heterotopia, giant cells), as well as on the developmental mechanisms likely to be involved in the abnormality (e.g., cell proliferation, migration). Recently, the genes responsible for several cortical dysplastic conditions have been identified and the underlying molecular processes investigated. However, it is still unclear how the various structural abnormalities associated with cortical dysplasia are related to (i.e., "cause") chronic seizures. To elucidate these relationships, a number of animal models of cortical dysplasia have been developed in rats and mice. Some models are based on laboratory manipulations that injure the brain (e.g., freeze, undercut, irradiation, teratogen exposure) of immature animals; others are based on spontaneous genetic mutations or on gene manipulations (knockouts/transgenics) that give rise to abnormal cortical structures. Such models of cortical ...Continue Reading

Citations

Jun 6, 2007·Journal of Neuropathology and Experimental Neurology·Véronique M AndréCarlos Cepeda
Mar 1, 2008·Cerebral Cortex·Raddy L RamosJoshua C Brumberg
Sep 9, 2008·Neurological Research·Canan Aykut-BingolGulsun Ekicioglu
May 25, 2012·Epilepsia·Philip A Schwartzkroin, H Jürgen Wenzel
Sep 22, 2011·Epilepsia·Naranzogt TschuluunPhilip A Schwartzkroin
Apr 21, 2018·Journal of Neurosurgery. Pediatrics·Rachel K RoweJonathan Lifshitz
Oct 24, 2007·The Journal of Comparative Neurology·Shilpa D Kadam, F Edward Dudek
Jan 27, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carl E Stafstrom
Feb 25, 2015·Nature Neuroscience·Brian P Grone, Scott C Baraban
Mar 23, 2011·Brain Research·Danielle M LipoffRaddy L Ramos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Mental Retardation and Developmental Disabilities Research Reviews
Philip A Schwartzkroin, C A Walsh
Epilepsia
Philip A Schwartzkroin, H Jurgen Wenzel
Frontiers in Psychiatry
Yuri BozziMatteo Caleo
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
H Jurgen WenzelPhilip A Schwartzkroin
© 2022 Meta ULC. All rights reserved