Cortical epileptogenesis and David Ferrier

Journal of the History of the Neurosciences
Mervyn J Eadie

Abstract

There was an increasing medical interest in the localization of representation of function in the cerebral cortex after Broca in 1861 identified a cortical area that appeared responsible for expressive speech. By the late 1860s, John Hughlings Jackson-based on clinico-pathological correlations mainly in persons with focal motor seizures-had reasoned that contralateral somatic motor function was represented in another area of the cortex. This localization was supported by Fritsch and Hitzig (1870) in experimental cortical stimulation studies in dogs. These authors also reported producing events resembling contralateral motor convulsing in their animals. Their work, and Jackson's ideas, prompted David Ferrier, in Great Britain, to begin a program of cerebral cortical stimulation studies in various vertebrate species, trying to locate cortical sites of representation of functions other than expressive speech and motor activity. In his initial report of his investigations (1873), he noted that appropriately sited Faradic stimulation evoked immediate or delayed contralateral focal motor seizures, some of which evolved into generalized convulsions. On this basis he reasoned that focal motor and generalized seizures were expressions o...Continue Reading

References

May 22, 2009·Epilepsy & Behavior : E&B·G Fritsch, E Hitzig
Jun 11, 1870·British Medical Journal·J T Dickson
Apr 26, 1873·British Medical Journal·D Ferrier

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