Cortical evoked responses associated with arousal from sleep

Derrick J PhillipsDavid M Rector


To determine if low-level intermittent auditory stimuli have the potential to disrupt sleep during 24-h recordings, we assessed arousal occurrence to varying stimulus intensities. Additionally, if stimulus-generated evoked response potential (ERP) components provide a metric of underlying cortical state, then a particular ERP structure may precede an arousal. Physiological electrodes measuring EEG, EKG, and EMG were implanted into 5 adult female Sprague-Dawley rats. We delivered auditory stimuli of varying intensities (50-75 dBa sound pressure level SPL) at random intervals of 6-12 s over a 24-hour period. Recordings were divided into 2-s epochs and scored for sleep/wake state. Following each stimulus, we identified whether the animal stayed asleep or woke. We then sorted the stimuli depending on prior and post-stimulus state, and measured ERP components. Auditory stimuli did not produce a significant increase in the number of arousals compared to silent control periods. Overall, arousal from REM sleep occurred more often compared to quiet sleep. ERPs preceding an arousal had decreased mean area and shorter N1 latency. Low level auditory stimuli did not fragment animal sleep since we observed no significant change in arousal oc...Continue Reading


Nov 1, 1979·Brain Research Bulletin·C ArnaudC Gottesmann
Jan 1, 1974·Psychophysiology·G W LangfordA J Pearson
Jan 1, 1973·Behaviour·N J Scourse, R A Hinde
Apr 1, 1994·Electroencephalography and Clinical Neurophysiology·G BarbatoT A Wehr
Feb 14, 1997·Neuroscience Letters·M PedemonteR A Velluti
Mar 25, 2000·Journal of Sleep Research·P J MurphyS S Campbell
May 16, 2001·Journal of Neurophysiology·M SteriadeF Grenier
Jan 29, 2002·Methods : a Companion to Methods in Enzymology·D M Rector, J S George
Nov 26, 2002·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·A M L Coenen, W H I M Drinkenburg
Sep 2, 2004·Journal of Sleep Research·T KatoG J Lavigne
May 11, 2005·Brain Research·David M RectorManuel J Rojas
Jul 14, 2007·Sleep Medicine Reviews·Ian M Colrain, Kenneth B Campbell
Nov 6, 2008·Nature Reviews. Neuroscience·James M KruegerJaak Panksepp
May 29, 2009·The European Journal of Neuroscience·David M RectorJames M Krueger

❮ Previous
Next ❯

Related Concepts

Related Feeds

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.