Cortical excitability in epilepsy and the impact of antiepileptic drugs: transcranial magnetic stimulation applications.

Expert Review of Neurotherapeutics
Sherifa Ahmed Hamed

Abstract

Epileptic conditions are characterized by impaired cortical excitation/inhibition balance and interneuronal disinhibition. Transcranial magnetic stimulation (TMS) is a neurophysiological method that assesses brain excitation/inhibition. This review was written after a detailed search in PubMed, EMBASE, ISI web of science, SciELO, Scopus, and Cochrane Controlled Trials databases from 1990 to 2020. It summarizes TMS applications for diagnostic and therapeutic purposes in epilepsy. TMS studies help to distinguish different epilepsy conditions and explore the antiepileptic drugs' (AEDs') effects on neuronal microcircuits and plasticity mechanisms. Repetitive TMS studies showed that low-frequency rTMS (0.33-1 Hz) can reduce seizures' frequency in refractory epilepsy or pause ongoing seizures; however, there is no current approval for its use in such patients as adjunctive treatment to AEDs. There are variable and conflicting TMS results which reflect the distinct pathogenic mechanisms of each epilepsy condition, the dynamic epileptogenic process over the long disease course resulting in the development of recurrent spontaneous seizures and/or progression of epilepsy after it is established, and the differential effect of AEDs on cor...Continue Reading

References

Jan 1, 1993·Clinical EEG (electroencephalography)·B J SteinhoffW Paulus
Jan 1, 1996·Electroencephalography and Clinical Neurophysiology·M D CaramiaG Bernardi
Jul 1, 1996·Acta Neurologica Scandinavica·R MichelucciC A Tassinari
Apr 1, 1997·Experimental Brain Research·H DevanneC Capaday
Sep 26, 1997·Neurology·R ChenM Hallett
Sep 15, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·A Pascual-LeoneM D Catalá
Apr 14, 1999·Journal of Neurophysiology·P M Steele, M D Mauk
Aug 15, 2000·Epilepsy Research·K J WerhahnS Noachtar
Sep 26, 2000·Electroencephalography and Clinical Neurophysiology·M InghilleriM Manfredi
Feb 22, 2001·Annual Review of Physiology·D A McCormick, D Contreras
Nov 28, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·V DelvauxA Maertens de Noordhout
Mar 7, 2002·Epilepsia·E A LukyanetzP G Kostyuk
Sep 23, 2003·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·M CincottaR Cantello
Nov 19, 2003·Psychopharmacology Bulletin·Michael J Owens, Charles B Nemeroff
May 4, 2004·Arquivos de neuro-psiquiatria·Joaquim P Brasil-NetoRaphael Boechat-Barros
Jun 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Berkley A LynchBruno Fuks
Jun 29, 2004·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·M TurazziniA Fiaschi
Aug 25, 2004·Seizure : the Journal of the British Epilepsy Association·Cengiz TatarogluBaris Baklan
Jan 25, 2005·Neuron·Ying-Zu HuangJohn C Rothwell
Mar 29, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Abraham ZangenMark Hallett
Apr 14, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H W LeeW H Theodore
Jun 11, 2005·Journal of the Neurological Sciences·Sonoko MisawaTakamichi Hattori
Jul 28, 2005·Seizure : the Journal of the British Epilepsy Association·Masako KinoshitaHiroshi Shibasaki

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