Cortical fibers orientation mapping using in-vivo whole brain 7 T diffusion MRI

NeuroImage
Omer F GulbanC Lenglet

Abstract

Diffusion MRI of the cortical gray matter is challenging because the micro-environment probed by water molecules is much more complex than within the white matter. High spatial and angular resolutions are therefore necessary to uncover anisotropic diffusion patterns and laminar structures, which provide complementary (e.g. to anatomical and functional MRI) microstructural information about the cortex architectonic. Several ex-vivo and in-vivo MRI studies have recently addressed this question, however predominantly with an emphasis on specific cortical areas. There is currently no whole brain in-vivo data leveraging multi-shell diffusion MRI acquisition at high spatial resolution, and depth dependent analysis, to characterize the complex organization of cortical fibers. Here, we present unique in-vivo human 7T diffusion MRI data, and a dedicated cortical depth dependent analysis pipeline. We leverage the high spatial (1.05 mm isotropic) and angular (198 diffusion gradient directions) resolution of this whole brain dataset to improve cortical fiber orientations mapping, and study neurites (axons and/or dendrites) trajectories across cortical depths. Tangential fibers in superficial cortical depths and crossing fiber configuration...Continue Reading

Citations

Oct 26, 2018·The British Journal of Radiology·Giuseppe BarisanoMeng Law
Jun 21, 2020·Journal of Magnetic Resonance Imaging : JMRI·Steen MoellerKamil Ugurbil
Aug 2, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mukund BalasubramanianJonathan R Polimeni
Dec 10, 2020·Scientific Reports·Faye McKennaMariana Lazar
Mar 3, 2021·NeuroImage. Clinical·R H G J van LanenO E M G Schijns
Aug 4, 2020·Progress in Neurobiology·Michelle MoerelFederico De Martino

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