Cortical Flow-Driven Shapes of Nonadherent Cells

Physical Review Letters
A C Callan-JonesR Voituriez

Abstract

Nonadherent polarized cells have been observed to have a pearlike, elongated shape. Using a minimal model that describes the cell cortex as a thin layer of contractile active gel, we show that the anisotropy of active stresses, controlled by cortical viscosity and filament ordering, can account for this morphology. The predicted shapes can be determined from the flow pattern only; they prove to be independent of the mechanism at the origin of the cortical flow, and are only weakly sensitive to the cytoplasmic rheology. In the case of actin flows resulting from a contractile instability, we propose a phase diagram of three-dimensional cell shapes that encompasses nonpolarized spherical, elongated, as well as oblate shapes, all of which have been observed in experiment.

References

Jul 11, 1991·Nature·J A Theriot, T J Mitchison
Mar 5, 2004·Physical Review Letters·K KruseK Sekimoto
Jul 11, 2006·Physical Biology·K KruseJ Prost
Jan 11, 2008·Physical Biology·G SalbreuxP Pullarkat
May 24, 2008·Nature·Kinneret KerenJulie A Theriot
Mar 5, 2009·Physical Review Letters·R J HawkinsR Voituriez
Oct 2, 2009·Physical Review Letters·G SalbreuxJ F Joanny
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Renaud PoinclouxPhilippe Chavrier
Mar 17, 2011·Physical Review Letters·Justin S BoisStephan W Grill
May 7, 2011·Annual Review of Biophysics·Martin LoosePetra Schwille
Oct 25, 2011·Science·Nathan W GoehringStephan W Grill
Jan 17, 2012·Physical Review Letters·K Doubrovinski, K Kruse
Jan 24, 2012·Developmental Cell·David Bilder, Saori L Haigo
Jul 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Elsen TjhungMichael E Cates
Jan 15, 2014·Biophysical Journal·Hervé TurlierJean-François Joanny
May 21, 2014·ELife·Enas Abu Shah, Kinneret Keren
Jul 17, 2014·Biophysical Journal·Philippe BunMaïté Coppey-Moisan
Feb 15, 2013·Physical Review Letters·C Blanch-Mercader, J Casademunt
Jan 22, 2015·Nature Communications·E TjhungM E Cates
Feb 14, 2015·Cell·Verena RuprechtCarl-Philipp Heisenberg
Mar 17, 2015·Nature Cell Biology·Martin BergertEwa K Paluch
Jun 17, 2015·Proceedings of the National Academy of Sciences of the United States of America·Edouard HannezoShigeo Hayashi

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Citations

Mar 16, 2018·Reports on Progress in Physics·Frank JülicherGuillaume Salbreux
Oct 23, 2018·ELife·Sundar Ram NaganathanStephan W Grill
Dec 21, 2018·Proceedings of the National Academy of Sciences of the United States of America·Alexander MietkeIvo F Sbalzarini
Jul 29, 2020·Proceedings of the National Academy of Sciences of the United States of America·Christian BächerStephan Gekle
Nov 26, 2019·Physical Review Letters·Alexander MietkeFrank Jülicher
Mar 12, 2019·Wiley Interdisciplinary Reviews. Computational Molecular Science·H G Othmer
Oct 8, 2016·Physical Review Letters·A C Callan-JonesR Voituriez
Oct 8, 2016·Physical Review Letters·L M Pismen
Jul 25, 2019·Physical Review. E·Christian Bächer, Stephan Gekle
Oct 2, 2019·Physical Review Letters·Alexander FarutinPierre Recho
Nov 9, 2017·Biophysical Journal·Elena F KosloverJulie A Theriot

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