Cortical Folding Pattern and its Consistency Induced by Biological Growth

Scientific Reports
Mir Jalil RazaviXianqiao Wang


Cortical folding, characterized by convex gyri and concave sulci, has an intrinsic relationship to the brain's functional organization. Understanding the mechanism of the brain's convoluted patterns can provide useful clues into normal and pathological brain function. In this paper, the cortical folding phenomenon is interpreted both analytically and computationally, and, in some cases, the findings are validated with experimental observations. The living human brain is modeled as a soft structure with a growing outer cortex and inner core to investigate its developmental mechanism. Analytical interpretations of differential growth of the brain model provide preliminary insight into critical growth ratios for instability and crease formation of the developing brain. Since the analytical approach cannot predict the evolution of cortical complex convolution after instability, non-linear finite element models are employed to study the crease formation and secondary morphological folds of the developing brain. Results demonstrate that the growth ratio of the cortex to core of the brain, the initial thickness, and material properties of both cortex and core have great impacts on the morphological patterns of the developing brain. La...Continue Reading


Nov 18, 2016·Scientific Reports·Tuo ZhangXianqiao Wang
Jul 6, 2017·Computer Methods in Biomechanics and Biomedical Engineering·Mir Jalil RazaviXianqiao Wang
Oct 3, 2017·Cerebral Cortex·Fangfei GeTianming Liu
Jun 28, 2018·Human Brain Mapping·Tuo ZhangTianming Liu
Apr 19, 2017·Journal of Biomechanical Engineering·Aref Samadi-DookiRhett W Stout
Sep 15, 2016·Physical Review. E·Mir Jalil RazaviXianqiao Wang
Mar 9, 2017·Journal of Computational Neuroscience·Tuo ZhangXianqiao Wang
Dec 15, 2018·Physical Review Letters·Maria HollandEllen Kuhl
Sep 2, 2017·Frontiers in Computational Neuroscience·Mir Jalil RazaviTianming Liu


Jun 14, 1975·Science·V S CavinessV S Caviness
Jan 1, 1989·Progress in Neurobiology·M A Hofman
Jan 1, 1988·Anatomy and Embryology·Karl ZillesH J Kretschmann
Jul 8, 1988·Science·P Rakic
Apr 1, 1994·Journal of Biomechanics·E K RodriguezA D McCulloch
Nov 5, 1998·Journal of Biomechanics·K B Arbogast, Susan S Margulies
May 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·K Zhang, T J Sejnowski
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·Bruce Fischl, Anders M Dale
Mar 17, 2001·Biological cybernetics·M A Changizi
May 11, 2002·Journal of Biomechanical Engineering·Michael T Prange, Susan S Margulies
Aug 17, 2002·Journal of Theoretical Biology·Julyan H E Cartwright
Oct 7, 2003·Annual Review of Neuroscience·Elizabeth A Grove, Tomomi Fukuchi-Shimogori
Feb 22, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Paul J McCrackenRichard L Ehman
Mar 11, 2005·Cerebral Cortex·Roberto Toro, Yves Burnod
May 4, 2005·Trends in Cognitive Sciences·Gerhard Roth, Ursula Dicke
Nov 30, 2005·Nature Reviews. Molecular Cell Biology·Magdalena Götz, Wieland B Huttner
Jan 18, 2006·European Journal of Radiology·Daniela PrayerPeter C Brugger
Oct 5, 2007·NeuroImage·Scott A KruseRichard L Ehman
May 13, 2008·The Neurologist·Trudy PangVolney L Sheen
Jul 25, 2008·Biomechanics and Modeling in Mechanobiology·Gang XuL A Taber
Feb 5, 2010·Journal of the Mechanical Behavior of Biomedical Materials·J A W van DommelenG W M Peters
Feb 24, 2010·NeuroImage·Jeffrey RogersDavid C Glahn
May 4, 2010·International Journal of Biological Macromolecules·Ruonan ZhangWan Jin Jahng
Jul 2, 2010·Journal of Biomechanical Engineering·G XuL A Taber
Jun 15, 2011·Cerebral Cortex·Emi TakahashiPatricia E Grant
Jul 21, 2011·Physical Review Letters·Bo LiHuajian Gao
Jul 30, 2011·Physical Review Letters·Julien DervauxMartine Ben Amar
Aug 3, 2011·Neuroimaging Clinics of North America·Charles Raybaud, Elysa Widjaja
Jan 18, 2012·NeuroImage·Bruce Fischl
Feb 7, 2013·Physical Review Letters·T TallinenL Mahadevan
Feb 19, 2013·Trends in Neurosciences·Karl ZillesKatrin Amunts
Apr 2, 2013·Cerebral Cortex·Lisa RonanPaul C Fletcher
Apr 10, 2013·Journal of the Mechanical Behavior of Biomedical Materials·P V BaylyC D Kroenke
May 15, 2013·NeuroImage·Matthew F GlasserWU-Minn HCP Consortium
Mar 19, 2014·Current Opinion in Neurobiology·Víctor Borrell, Magdalena Götz
Jul 11, 2014·Scientific Reports·Silvia BuddayEllen Kuhl
Aug 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Tuomas TallinenL Mahadevan
Sep 10, 2014·Journal of the Mechanics and Physics of Solids·Silvia BuddayEllen Kuhl
Sep 18, 2014·Journal of Child Neurology·Birendra RaiLiz Elizabeth Dunbar

Related Concepts

Developmental Growth Involved in Morphogenesis
Cortex Bone Disorders
Adrenal Cortex Diseases
Finite Element Analysis
Structure of Cortex of Kidney
Brain Function

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Sexual Dimorphism in Neurodegeneration

There exist sex differences in neurodevelopmental and neurodegenerative disorders. For instance, multiple sclerosis is more common in women, whereas Parkinson’s disease is more common in men. Here is the latest research on sexual dimorphism in neurodegeneration

HLA Genetic Variation

HLA genetic variation has been found to confer risk for a wide variety of diseases. Identifying these associations and understanding their molecular mechanisms is ongoing and holds promise for the development of therapeutics. Find the latest research on HLA genetic variation here.

Super-resolution Microscopy

Super-resolution microscopy is the term commonly given to fluorescence microscopy techniques with resolutions that are not limited by the diffraction of light. Here are the latest discoveries pertaining to super-resolution microscopy.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.

Brain Lower Grade Glioma

Low grade gliomas in the brain form from oligodendrocytes and astrocytes and are the slowest-growing glioma in adults. Discover the latest research on these brain tumors here.

CD4/CD8 Signaling

Cluster of differentiation 4 and 8 (CD8 and CD8) are glycoproteins founds on the surface of immune cells. Here is the latest research on their role in cell signaling pathways.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

Journal of the Mechanics and Physics of Solids
Silvia BuddayEllen Kuhl
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Rosita ShishegarLeigh A Johnston
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Reza Rajimehr, Roger B H Tootell
PLoS Computational Biology
Julien Lefèvre, Jean-François Mangin
Proceedings of the National Academy of Sciences of the United States of America
Tuomas TallinenL Mahadevan
© 2020 Meta ULC. All rights reserved