Cortical Gyrification, Psychotic-Like Experiences, and Cognitive Performance in Nonclinical Subjects.

Schizophrenia Bulletin
Ulrika EvermannIgor Nenadić

Abstract

Psychotic-like experiences (PLE) are present in nonclinical populations, yet their association with brain structural variation, especially markers of early neurodevelopment, is poorly understood. We tested the hypothesis that cortical surface gyrification, a putative marker of early brain development, is associated with PLE in healthy subjects. We analyzed gyrification from 3 Tesla MRI scans (using CAT12 software) and PLE (positive, negative, and depressive symptom dimensions derived from the Community Assessment of Psychic Experiences, CAPE) in 103 healthy participants (49 females, mean age 29.13 ± 9.37 years). A subsample of 63 individuals completed tasks from the Wechsler Adult Intelligence Scale and Controlled Oral Word Association Test. Estimated IQ and a composite neuropsychological score were used to explore mediation pathways via cognition. Positive PLE distress was negatively associated with gyrification of the left precuneus. PLE depression dimension showed a negative association with gyrification in the right supramarginal and temporal region. There was no significant mediating effect of cognition on these associations. Our results support a neurobiological psychosis spectrum, for the first time linking an early deve...Continue Reading

References

Jan 1, 1994·Archives of Neurology·G J ReyK Nedd
Nov 6, 2003·Statistical Methods in Medical Research·Thomas Nichols, Satoru Hayasaka
May 4, 2007·The American Journal of Psychiatry·Raquel E GurRuben C Gur
Jan 19, 2008·The British Journal of Psychiatry. Supplement·Stefan J BorgwardtAnita Riecher-Rössler
May 6, 2009·Neuropsychology·Raquelle I Mesholam-GatelyLarry J Seidman
Nov 18, 2009·Psychological Medicine·G ModinosP K McGuire
Jun 12, 2010·Psychiatry Research·Nikolaos MakrisJill M Goldstein
Jun 12, 2010·Schizophrenia Bulletin·Ulrich EttingerMarco Picchioni
Oct 12, 2010·Schizophrenia Bulletin·Tim B ZiermansSarah Durston
Jan 25, 2011·Biological Psychiatry·Lena PalaniyappanPeter F Liddle
Feb 9, 2011·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jennifer H BarnettPeter B Jones
Oct 26, 2011·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Ulrich EttingerNikolaos Koutsouleris
Jan 11, 2012·Journal of Visualized Experiments : JoVE·Marie SchaerStephan Eliez
Mar 27, 2012·Comprehensive Psychiatry·Davide SistiDonatella R Petretto
Jun 6, 2012·Archives of General Psychiatry·Paolo Fusar-PoliStefan Borgwardt
Jun 14, 2012·Brain : a Journal of Neurology·Sheena F OwensTimothea Toulopoulou
Aug 22, 2012·Psychiatry Research·Emily KlineJason Schiffman
Feb 19, 2013·Trends in Neurosciences·Karl ZillesKatrin Amunts
Apr 12, 2013·Social Cognitive and Affective Neuroscience·Veronika I MüllerSimon B Eickhoff
May 8, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Ximena GoldbergTimothea Toulopoulou
Feb 26, 2014·Journal of the American Academy of Child and Adolescent Psychiatry·Katherine A EpsteinSanjiv Kumra
Mar 22, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gang LiDinggang Shen
Apr 29, 2014·Brain Structure & Function·Lena PalaniyappanPeter Liddle
Jul 17, 2014·The British Journal of Psychiatry : the Journal of Mental Science·Joseph KambeitzOliver D Howes
Jul 19, 2014·Biological Psychiatry·Tyrone D CannonUNKNOWN North American Prodrome Longitudinal Study Consortium
Oct 7, 2014·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Marta BosiaRoberto Cavallaro

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Jan 19, 2021·NeuroImage·Rosita ShishegarLeigh A Johnston

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