Cortical kainate receptors and behavioral anxiety

Molecular Brain
Min Zhuo

Abstract

The study of glutamatergic synapses mainly focuses on the memory-related hippocampus. Recent studies in the cortical areas such as the anterior cingulate cortex (ACC) show that excitatory synapses can undergo long-term plastic changes in adult animals. Long-term potentiation (LTP) of cortical synapses may play important roles in chronic pain and anxiety. In addition to NMDA and AMPA receptors, kainate (KA) receptors have been found to play roles in synaptic transmission, regulation and presynaptic forms of LTP. In this brief review, I will summarize the new progress made on KA receptors, and propose that ACC synapses may provide a good synaptic model for understanding cortical mechanism for behavioral anxiety, and its related emotional disorders.

References

Jan 7, 1993·Nature·T V Bliss, G L Collingridge
May 23, 2001·Nature Neuroscience·H LiM A Rogawski
Jun 23, 2004·Nature Reviews. Neuroscience·Cornelius Gross, Rene Hen
Oct 12, 2004·Molecular Neurobiology·Maria F M BragaHe Li
Jan 6, 2005·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Alexander E Dityatev, Vadim Y Bolshakov
Jan 28, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shanelle KoMin Zhuo
Jun 2, 2005·Journal of Neurophysiology·Long-Jun WuMin Zhuo
Jul 5, 2005·Nature Reviews. Neuroscience·Brent A Vogt
Apr 28, 2007·Magnetic Resonance Imaging·Richard G WiseIrene Tracey
May 17, 2007·Current Pharmaceutical Design·Long-Jun WuMin Zhuo
Jan 18, 2008·Nature Reviews. Neuroscience·Paul TiesingaTerrence J Sejnowski
Apr 4, 2008·Neurochemical Research·Long-Jun WuMin Zhuo
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ryong-Moon ShinVadim Y Bolshakov
Aug 4, 2011·Clinics·Timothy V P Bliss, Sam F Cooke
Jan 19, 2012·Journal of Neurochemistry·José Vicente Negrete-DíazAntonio Rodríguez-Moreno
Jul 13, 2012·Journal of Neurophysiology·Kohei KogaMin Zhuo
Aug 17, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·SukJae Joshua KangMin Zhuo
Jan 5, 2013·The EMBO Journal·Mario CartaChristophe Mulle
Jan 24, 2013·Molecular Brain·Tim V P Bliss, Graham L Collingridge
May 29, 2013·Psychiatry and Clinical Neurosciences·Jonathan C IpserDan J Stein
May 31, 2013·Nature Reviews. Neuroscience·M Catherine BushnellLucie A Low
Jun 21, 2013·Nature Reviews. Neuroscience·Dan W Grupe, Jack B Nitschke
Aug 13, 2013·The European Journal of Neuroscience·Ming-Gang LiuMin Zhuo
Oct 22, 2013·Neuron·Juan Lerma, Joana M Marques
Aug 8, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Xiang-Yao LiMin Zhuo
Jan 17, 2015·Nature·Patricia H Janak, Kay M Tye
Feb 6, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kohei KogaMin Zhuo
May 21, 2015·Nature Reviews. Neuroscience·Philip TovoteAndreas Lüthi
Jun 5, 2015·PloS One·Stephanie BoehmeThomas Straube
Oct 9, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·M Isabel AllerJuan Lerma
Feb 18, 2016·Trends in Neurosciences·Min Zhuo
May 15, 2016·Molecular Pain·Manabu YamanakaMin Zhuo
Jun 17, 2016·Nature Reviews. Neuroscience·Tim V P BlissMin Zhuo
Aug 26, 2016·The Journal of Comparative Neurology·Minela HadzicPetra Wahle
Nov 2, 2016·The American Journal of Psychiatry·Joseph E LeDoux, Daniel S Pine

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Citations

Oct 12, 2018·Neurochemical Research·Caroline L ScholefieldElek Molnár
Nov 11, 2020·Neuroscience and Biobehavioral Reviews·Salar VaseghiMohammad-Reza Zarrindast
May 1, 2021·International Journal of Molecular Sciences·Elisa Ren, Giulia Curia

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