Cortical laminar thickness and column spacing in human temporal and inferior parietal lobes: intra-individual anatomical relations

Laterality
H Lee Seldon

Abstract

Harasty, Seldon, Chan, Halliday, and Harding (2003) and Seldon (2005) have proposed a "balloon model" which suggests that myelin growth stretches the cerebral cortex, causing the cortical thickness to decrease and the columnar spacing to increase, in turn affecting the cortical capacity to differentiate afferent signals. This has been tested using temporal lobe (area TA) and inferior parietal lobule (areas PG, PF) histological specimens from human donors. The temporal and inferior parietal regions differ in ways that have never been described. Correlations between the thickness of laminae II-III and columnar spacing in lamina III within individual cytoarchitectonic areas in both hemispheres of each donor were calculated. Those in areas PG/PF are predominantly negative in both hemispheres, as predicted by the model. This is also true for the left hemisphere TA, but the right hemisphere TA shows no correlations between thickness and spacing. Comparisons of thickness and spacing between left and right hemispheres in PG/PF of each donor show no consistent direction, whereas those in TA fairly consistently show thinner laminae and wider column intervals on the left. In the left area TA, females have thinner laminae than males. Thus,...Continue Reading

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Citations

Sep 10, 2013·Schizophrenia Research·J Tilak RatnanatherPatrick E Barta
Apr 13, 2010·Neurobiology of Aging·Thomas EspesethIvar Reinvang
Apr 7, 2012·Critical Care Research and Practice·Constantino Jose Fernandes, Murillo Santucci Cesar de Assuncao

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