Cortical lesions in multiple sclerosis.

Nature Reviews. Neurology
M CalabreseP Gallo

Abstract

Multiple sclerosis (MS) is typically considered to be a chronic inflammatory-demyelinating disease of CNS white matter. In the past decade, however, pathological and MRI studies have shown that lesions are often located in the gray matter, especially in the cerebral cortex. The histopathological characteristics of these cortical lesions differ substantially from lesions located in the white matter, which suggests location-dependent expression of the MS immunopathological process. Double inversion recovery imaging--an MRI technique that selectively images gray matter and lesions--has enabled researchers to image cortical lesions in vivo. Double inversion recovery studies have shown that cortical lesions can be detected at the earliest clinical stages of MS, and cortical lesion burden positively correlates with the severity of physical and cognitive impairments. These gray matter lesions are also independent predictors of subsequent disease evolution. This Review provides a summary of the main histopathological and MRI findings with regard to cortical lesions in MS, and indicates that increasing our understanding of cortical lesions has increased our knowledge of MS pathobiology.

References

Dec 2, 1975·Journal of Neurology·A Guseo, K Jellinger
Mar 2, 1999·Brain : a Journal of Neurology·D KiddT Revesz
Mar 17, 2000·Neurology·J H SimonN Simonian
Jun 20, 2002·Journal of Neuropathology and Experimental Neurology·John W PetersonBruce D Trapp
Jun 14, 2003·Brain : a Journal of Neurology·Michael SailerAnders Dale
Aug 7, 2003·Journal of Neuropathology and Experimental Neurology·Lars BøSverre J Mørk
Aug 21, 2003·Multiple Sclerosis : Clinical and Laboratory Research·L BøS J Mørk
Nov 1, 1962·Journal of Neurology, Neurosurgery, and Psychiatry·B BROWNELL, J T HUGHES
Aug 26, 2004·Multiple Sclerosis : Clinical and Laboratory Research·D T ChardD H Miller
Jun 15, 2005·Molecular Neurobiology·Qun WangAlbert Y Sun
Aug 3, 2005·Neurobiology of Disease·Ainara Vallejo-IllarramendiCarlos Matute
Oct 19, 2005·Brain : a Journal of Neurology·Alexandra KutzelniggHans Lassmann
Dec 2, 2005·Journal of Neuropathology and Experimental Neurology·Marco VercellinoPaola Cavalla
Apr 22, 2006·Journal of the Neurological Sciences·Marco RovarisMassimo Filippi
Apr 29, 2006·Journal of the Neurological Sciences·Maria Pia AmatoEmilio Portaccio
Feb 28, 2007·Neurology·Istvan PirkoRohit Bakshi
Mar 29, 2007·Brain Pathology·Monika AlbertChristine Stadelmann
Apr 3, 2007·Journal of the Neurological Sciences·Arnaud Charil, Massimo Filippi
Apr 7, 2007·Journal of Neuropathology and Experimental Neurology·Jack van HorssenLars Bø
Jun 7, 2007·Brain : a Journal of Neurology·Reiner Sprengelmeyer
Sep 7, 2007·Journal of Neuropathology and Experimental Neurology·Jeroen J G GeurtsPaul van der Valk
Oct 11, 2007·Annals of Neurology·Assunta Dal BiancoHans Lassmann
Nov 7, 2007·The Journal of Experimental Medicine·Barbara SerafiniFrancesca Aloisi
Jan 30, 2008·Journal of Neurology·Massimiliano CalabresePaolo Gallo
Jan 31, 2008·Journal of Neurology·Jeroen J G GeurtsFrederik Barkhof
May 22, 2008·Brain Pathology·Dimitrios PapadopoulosRichard Reynolds
Jul 29, 2008·Annals of Neurology·Elizabeth FisherRichard A Rudick
Aug 16, 2008·Lancet Neurology·Jeroen J G Geurts, Frederik Barkhof
Aug 30, 2008·Multiple Sclerosis : Clinical and Laboratory Research·M CalabreseP Gallo
Jul 30, 2009·Brain : a Journal of Neurology·Simon N WillisKevin C O'Connor

❮ Previous
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Citations

Jun 1, 2011·Acta Neuropathologica·Richard ReynoldsOwain Howell
Jun 21, 2012·Journal of Neurology·Martina AbsintaMassimo Filippi
Dec 23, 2011·Clinical Reviews in Allergy & Immunology·Jin NakaharaNorihiro Suzuki
Jan 1, 2014·Clinical Neurology and Neurosurgery·V V Brinar, B Barun
Dec 14, 2011·The New England Journal of Medicine·Claudia F LucchinettiRichard M Ransohoff
Aug 16, 2011·Brain : a Journal of Neurology·Owain W HowellRichard Reynolds
Aug 22, 2012·Brain : a Journal of Neurology·Sung R ChoiRichard Reynolds
May 21, 2013·Brain : a Journal of Neurology·Smriti M AgrawalV Wee Yong
Oct 1, 2011·Topics in Magnetic Resonance Imaging : TMRI·Antonio José da RochaAntonio Carlos Martins Maia
Dec 8, 2011·BMC Neurology·Caroline A WalkerKevin C O'Connor
Mar 9, 2012·BMC Neurology·Bogdan F Gh Popescu, Claudia F Lucchinetti
Aug 7, 2013·Continuum : Lifelong Learning in Neurology·Bogdan F Gh PopescuClaudia F Lucchinetti
Feb 15, 2011·Pakistan Journal of Biological Sciences : PJBS·Zinat MiabiDariush Moghinan
Jul 23, 2013·Molecular Neurobiology·Arash NazeriAmit Bar-Or
Feb 20, 2014·Der Nervenarzt·J KuchlingJ Wuerfel
Sep 17, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Laëtitia DebernardDeborah F Mason
Jan 5, 2011·Autoimmune Diseases·Giulio DisantoJulia M Morahan
Dec 3, 2014·Clinical Neurology and Neurosurgery·Murat YildizStefan Borgwardt
Apr 16, 2011·AJNR. American Journal of Neuroradiology·M AbsintaM Filippi
Feb 18, 2016·Journal of Neurology·Martina AbsintaMassimo Filippi
Apr 24, 2013·Neuroimaging Clinics of North America·Leonard H Verhey, John G Sled
Apr 29, 2011·Progress in Neurobiology·Ulf ZiemannHayrettin Tumani
Aug 8, 2014·Journal of Neuropathology and Experimental Neurology·Kyriaki MarkoullisKleopas A Kleopa
Dec 18, 2012·Journal of Neuropathology and Experimental Neurology·Roberta MagliozziFrancesca Aloisi
Dec 1, 2015·Journal of Neuroimmunology·Priya ChaudharyDennis Bourdette
Oct 31, 2014·Annals of Clinical and Translational Neurology·Guillaume BonnierCristina Granziera
Nov 21, 2013·British Journal of Clinical Pharmacology·Alan M Palmer
Nov 26, 2015·Journal of Magnetic Resonance Imaging : JMRI·Mário João FartariaCristina Granziera
Sep 22, 2015·Frontiers in Neurology·Elise HoudayerLetizia Leocani
Jul 24, 2014·Human Brain Mapping·Prejaas TewarieArjan Hillebrand
Mar 24, 2012·Lancet Neurology·Massimo FilippiUNKNOWN Attendees of the Correlation between Pathological MRI findings in MS workshop
Mar 12, 2013·Multiple Sclerosis International·Stephanie B SycDaniel S Reich
Feb 24, 2015·Nature Reviews. Neuroscience·Massimiliano CalabreseRoland Martin
Mar 17, 2015·Lancet Neurology·Daniel OntanedaJeremy Chataway

❮ Previous
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