PMID: 8584681Oct 1, 1995Paper

Cortical mapping of Alzheimer pathology in brains of aged non-demented subjects

Progress in Neuro-psychopharmacology & Biological Psychiatry
P VermerschA Delacourte

Abstract

1. The presence of Alzheimer-type neurofibrillary pathology and amyloid deposits within the brains of 27 aged non-demented subjects was investigated by immunoblotting and immunohistochemistry using antibodies directed against pathological Tau proteins 55, 64 and 69 and beta A4 respectively. 2. The abnormal Tau triplet, a biochemical marker of neurofibrillary degeneration was quantified by western blot and densitometric analysis in several cortical areas including the entorhinal cortex (EC), hippocampus and Brodmann areas (BA) 38, 20, 22, 35, 9, 44 and 39. 3. The abnormal Tau triplet was detected in the EC and the hippocampus of most of the controls aged over 70 years. In few control cases abnormal Tau proteins were also detected in the isocortex, in BA38 alone or also in BA20. Some cases and especially those with Tau pathology in the temporal lobe contained numerous senile plaques (SP) in the neocortex. 4. The authors conclude that control cases with Tau pathology in the temporal lobe and numerous SP in the neocortex were likely to be subclinical stages of AD whereas others with Tau pathology exclusively detected in the EC and hippocampus and without or few SP in the neocortex were related to normal aging.

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Apr 1, 1990·Neuropathology and Applied Neurobiology·B M HubbardJ M Anderson
Sep 1, 1989·Journal of the Neurological Sciences·S FlamentA Défossez
Nov 1, 1985·Archives of Neurology·Z S Khachaturian
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R C PearsonT P Powell
May 16, 1984·Biochemical and Biophysical Research Communications·G G Glenner, C W Wong

❮ Previous
Next ❯

Citations

Feb 22, 2003·NeuroImage·Gaël Chetelat, Jean-Claude Baron
May 29, 2004·Neurobiology of Aging·Paul A Adlard, Brian J Cummings
Aug 20, 2005·Brain Research. Developmental Brain Research·Wencheng YangMichael J Strong
Aug 31, 2007·The International Journal of Neuroscience·Ilya D Ionov
Mar 30, 2018·Frontiers in Behavioral Neuroscience·Yu-Chen ChenJian-Ping Gu
Jan 20, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Joseph SeemillerUNKNOWN and the Alzheimer’s Disease Neuroimaging Initiative
Sep 1, 2000·Brain Research. Brain Research Reviews·L BuéeP R Hof

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: Tau & TDP-43

Alzheimer's disease is a neurodegenerative disease. This feed focuses on the underlying role of tau proteins and TAR DNA-binding protein 43, as well as other genetic factors, in Alzheimer's disease.