Cortical Matrix Mineral Density Measured Noninvasively in Pre- and Postmenopausal Women and a Woman With Vitamin D-Dependent Rickets

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Cherie Y ChiangE Seeman

Abstract

Reduced bone mineral density (BMD) may be due to reduced mineralized bone matrix volume, incomplete secondary mineralization, or reduced primary mineralization. Because bone biopsy is invasive, we hypothesized that noninvasive image acquisition at high resolution can accurately quantify matrix mineral density (MMD). Quantification of MMD was confined to voxels attenuation photons above 80% of that produced by fully mineralized bone matrix because attenuation at this level is due to variation in mineralization, not porosity. To assess accuracy, 9 cadaveric distal radii were imaged at a voxel size of 82 microns using high-resolution peripheral quantitative computed tomography (HR-pQCT; XtremeCT, Scanco Medical AG, Bruttisellen, Switzerland) and compared with VivaCT 40 (µCT) at 19-micron voxel size. Associations between MMD and porosity were studied in 94 healthy vitamin D-replete premenopausal women, 77 postmenopausal women, and in a 27-year-old woman with vitamin D-dependent rickets (VDDR). Microstructure and MMD were quantified using StrAx (StraxCorp, Melbourne, Australia). MMD measured by HR-pQCT and µCT correlated (R = 0.87; p < 0.0001). The precision error for MMD was 2.43%. Cortical porosity and MMD were associated with age...Continue Reading

References

Jun 24, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ozan AkkusMitchell B Schaffler
Feb 7, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Allan G NeedChristopher Nordin
Dec 7, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Galateia J KazakiaSharmila Majumdar
Jul 4, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Allan G NeedB E Christopher Nordin
Aug 8, 2008·Calcified Tissue International·Andrew J BurghardtSharmila Majumdar
Jul 15, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Matthias PriemelMichael Amling
Jan 22, 2010·Journal of Bone and Mineral Metabolism·Delphine FarlayGeorges Boivin
Oct 12, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ego Seeman
Dec 17, 2010·The Journal of Clinical Endocrinology and Metabolism·A J SaiJ C Gallagher
Aug 6, 2013·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Stephanie BoutroyJohn P Bilezikian
Jul 22, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joy N TsaiBenjamin Z Leder
Oct 21, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Y BalaE Seeman

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Citations

Nov 7, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R Vieth
Apr 1, 2020·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Ko ChibaKosei Yoh
Jul 17, 2021·Current Osteoporosis Reports·Lindsay L LoundagainW Brent Edwards

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