Cortical metabolic changes in the cerebellar variant of multiple system atrophy: a voxel-based FDG-PET study in 41 patients

NeuroImage
Phil Hyu LeeSeok Nam Yoon

Abstract

In addition to neuronal loss in the cerebellum and basal ganglia, recent imaging studies have suggested that cortical involvement may be more extensive in patients with MSA. In this study, we focused on cortical metabolic patterns in 41 patients with MSA-C and 30 controls, using statistical parametric mapping analysis to evaluate whether metabolic derangement in MSA-C patients involved the cortical area and correlated cerebral metabolism with clinical parameters. In patients with MSA-C, SPM analysis revealed that, apart from the expected reduction of FDG-uptake in brainstem-cerebellar area, there was a significant hypometabolism in widespread frontal cortex, including inferior orbitofrontal, rectus, middle and superior frontal, and superior mesiofrontal extending to cingulum, and left inferior parietal cortex. In a subgroup analysis of MSA-C patients, metabolic derangement in the cerebral cortex was visible even in the early stages of MSA-C. In advanced stages, the metabolic derangement tended to evolve into the rostral brainstem and into other cortical areas, including left inferior frontal cortex and right inferior orbitofrontal, right anterior and middle cingulate, and anterior portion of superior mesiofrontal gyri. In corre...Continue Reading

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Citations

May 28, 2009·Journal of Neurology·Gregor K Wenning, Nadia Stefanova
May 27, 2009·Journal of Neurology·Tae Sung LimSeok Woo Yong
Dec 11, 2013·Clinical Nuclear Medicine·Ümit Özgür AkdemirLütfiye Özlem Kapucu
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Aug 9, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Matthew R Burns, Nikolaus R McFarland
Oct 18, 2019·Parkinsonism & Related Disorders·Stephan GrimaldiAlexandre Eusebio

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