Cortical Microinfarcts in Patients with Middle Cerebral Artery Stenosis

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
Xinyi LengLiping Liu

Abstract

Cortical microinfarcts (CMIs) have been correlated to cognitive decline and dementia. It was previously considered only visible on microscope, but was recently reported to be visible on 3.0 Tesla magnetic resonance imaging (MRI) and linked to presence of intracranial stenosis. We aimed to investigate CMIs on 3.0 Tesla MRI in patients with M1 middle cerebral artery (MCA-M1) stenosis. Patients with a recent non-cardioembolic ischemic stroke or transient ischemic attack and an atherosclerotic MCA-M1 stenosis were recruited. The severity of MCA stenosis was defined as moderate (50%-69%) or severe (70%-99% or focal flow void) on time-of-flight MR angiography (MRA). The distal to proximal signal intensity ratio (SIR) of MCA stenosis was measured on time-of-flight MRA to represent its hemodynamic significance. The presence of CMI(s) in the ipsilateral hemisphere was assessed on axial T1- or T2-weighted images and T2-weighted fluid-attenuated inversion-recovery images. Overall, 86 patients (mean age: 62.8 years; 77.9% males) were analyzed, 66 (76.7%) and 20 (23.3%), respectively, having moderate and severe MCA-M1 stenoses. The median SIR was .91. Forty-five (52.3%) patients had ipsilateral CMI(s). Multivariate logistic regression showe...Continue Reading

Citations

Sep 28, 2017·Journal of Neurochemistry·David A HartmannAndy Y Shih
Aug 20, 2020·Stroke; a Journal of Cerebral Circulation·Yufei WeiUNKNOWN Co-Investigators
May 16, 2019·Stroke; a Journal of Cerebral Circulation·Sharmila SagnierIgor Sibon
Sep 10, 2019·Journal of Neuroscience Research·Sharmila Sagnier, Igor Sibon
Mar 15, 2020·Acta Neuropathologica Communications·Deniz Yilmazer-HankeVolker Rasche

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