Cortical morphometry and neural dysfunction in Huntington's disease: a review.

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Brendan TanNellie Georgiou-Karistianis

Abstract

Numerous neuroimaging techniques have been used to identify biomarkers of disease progression in Huntington's disease (HD). To date, the earliest and most sensitive of these is caudate volume; however, it is becoming increasingly evident that numerous changes to cortical structures, and their interconnected networks, occur throughout the course of the disease. The mechanisms by which atrophy spreads from the caudate to these cortical regions remains unknown. In this review, the neuroimaging literature specific to T1-weighted and diffusion-weighted magnetic resonance imaging is summarized and new strategies for the investigation of cortical morphometry and the network spread of degeneration in HD are proposed. This new avenue of research may enable further characterization of disease pathology and could add to a suite of biomarker/s of disease progression for patient stratification that will help guide future clinical trials.

References

Dec 9, 1991·Neuroscience Letters·J C HedreenC A Ross
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A ReinerA B Young
Nov 1, 1985·Journal of Neuropathology and Experimental Neurology·J P VonsattelE P Richardson
Aug 1, 1993·Archives of Neurology·J L Cummings
Dec 1, 1995·Journal of Clinical and Experimental Neuropsychology·J BrandtC A Gow
Dec 1, 1996·Archives of Neurology·E H AylwardJ Brandt
Jan 27, 1998·Neurology·E H AylwardC A Ross
May 22, 1998·Journal of Neuropathology and Experimental Neurology·J P Vonsattel, M DiFiglia
Sep 24, 1998·Journal of the International Neuropsychological Society : JINS·J R CampodonicoJ Brandt
Jun 23, 1999·Acta Neuropathologica·H HeinsenC Schmitz
Jun 1, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·E H AylwardC A Ross
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Jul 24, 2002·Brain : a Journal of Neurology·M J ThiebenR S J Frackowiak
Sep 23, 2003·Clinical Chemistry·Russell L Margolis, Christopher A Ross
Oct 7, 2004·Psychiatry Research·Antonio Y HardanNancy J Minshew
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Richard H Myers
Apr 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·C M KippsE A McCusker
Jun 23, 2005·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Leigh J BeglingerJane S Paulsen
Aug 23, 2005·Biological Psychiatry·Jane S PaulsenPeg C Nopoulos
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerMark A Mintun
Oct 4, 2005·Psychiatry Research·Sarah A J ReadingChristopher A Ross
Dec 20, 2005·Journal of Neural Transmission·R M RidleyR M Cummings
Mar 30, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·Klaus SeppiGregor K Wenning
Jun 7, 2006·Movement Disorders : Official Journal of the Movement Disorder Society·H Diana RosasDavid H Salat
Jun 14, 2006·Archives of Neurology·Jane S PaulsenUNKNOWN Predict-HD Investigators of the Huntington Study Group
Jun 30, 2006·Trends in Neurosciences·Lary C WalkerMathias Jucker
Jan 24, 2007·Lancet·Francis O Walker
Mar 31, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Mark MühlauAlexander Peinemann
May 9, 2007·Neuroscience Letters·Sandra E LehAntonio P Strafella

❮ Previous
Next ❯

Citations

Jan 19, 2021·NeuroImage·Rosita ShishegarLeigh A Johnston

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.