DOI: 10.1101/516260Jan 9, 2019Paper

Cortical network mechanisms of anodal and cathodal transcranial direct current stimulation in awake primates

BioRxiv : the Preprint Server for Biology
Andrew R BogaardEberhard Fetz

Abstract

Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that is widely used to stimulate the sensorimotor cortex, and yet the mechanism by which it influences the natural activity of cortical networks is still under debate. Here, we characterize the effects of anodal and cathodal tDCS on underlying neurons in active macaque sensorimotor cortex across a range of doses. We find changes in spike rates that are sensitive to both current intensity and polarity, behavioral state, and that are cell-type specific. At high currents, effects persist after the offset of stimulation, and the spatiotemporal activity associated with motor activity of the contralateral limb, measured by dynamics of neural ensembles, are altered. These data suggest that tDCS induces reproducible and noticeable changes in cortical neuron activity and support the theory that it affects brain activity through a combination of single neuron polarization and network interactions.

Related Concepts

Cerebral Cortex
Limb Structure
Neurons
Ultrasonography, Doppler, Transcranial
Contralateral
Brain Activity
Polarization
Percutaneous Neuromodulation Therapy
Neuron of Cerebral Cortex
Sensorimotor Cortex

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