Cortical Network Topology in Prodromal and Mild Dementia Due to Alzheimer's Disease: Graph Theory Applied to Resting State EEG

Brain Topography
Raffaella FranciottiLaura Bonanni

Abstract

Graph theory analysis on resting state electroencephalographic rhythms disclosed topological properties of cerebral network. In Alzheimer's disease (AD) patients, this approach showed mixed results. Granger causality matrices were used as input to the graph theory allowing to estimate the strength and the direction of information transfer between electrode pairs. The number of edges (degree), the number of inward edges (in-degree), of outgoing edges (out-degree) were statistically compared among healthy controls, patients with mild cognitive impairment due to AD (AD-MCI) and AD patients with mild dementia (ADD) to evaluate if degree abnormality could involve low and/or high degree vertices, the so called hubs, in both prodromal and over dementia stage. Clustering coefficient and local efficiency were evaluated as measures of network segregation, path length and global efficiency as measures of integration, the assortativity coefficient as a measure of resilience. Degree, in-degree and out-degree values were lower in AD-MCI and ADD than the control group for non-hubs and hubs vertices. The number of edges was preserved for frontal electrodes, where patients' groups showed an additional hub in F3. Clustering coefficient was lower...Continue Reading

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Citations

Aug 17, 2020·Cerebral Cortex·Laura BonanniUNKNOWN FTD Italian study group-SINDEM
Dec 29, 2020·International Journal of Neural Systems·Fo HuTao Zhang
Apr 17, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Claudio BabiloniBahar Guntekin
May 28, 2021·Cognitive Neurodynamics·Zhongke GaoMatjaž Perc
Jul 30, 2021·Frontiers in Aging Neuroscience·Laura M WrightAnnalena Venneri
Jul 10, 2020·Journal of Behavioral Addictions·Hongxia WangYan Liu
Nov 16, 2021·Frontiers in Computational Neuroscience·Nadia YoussefYingjie Li

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