Cortical oxygenation during exposure therapy - in situ fNIRS measurements in arachnophobia.

NeuroImage. Clinical
David RosenbaumAnn-Christine Ehlis

Abstract

Exposure therapy is a well-studied and highly efficacious treatment for phobic disorders. Although the neurobiological model of fear is well underpinned by various studies, the mechanisms of exposure therapy are still under discussion. Partly, this is due to the fact that most neurophysiological methods like fMRI are not able to be used in the natural therapeutic settings. The current study used in situ measurements of cortical blood oxygenation (O2Hb) during exposure therapy by means of functional near-infrared spectroscopy. 37 subjects (N = 30 completers) underwent exposure therapy during 5 adapted sessions in which subjects were exposed to Tegenaria Domestica (domestic house spider - experimental condition) and Dendrobaena Veneta/ Eisenaia hortensis (red earthworm - control condition). Compared to the control condition, patients showed higher O2Hb levels in the anticipation and exposure phase of spider exposure in areas of the cognitive control network (CCN). Further, significant decreases in O2Hb were observed during the session accompanied by reductions in fear related symptoms. However, while symptoms decreased in a linear quadratic manner, with higher reductions in the beginning of the session, CCN activity decreased lin...Continue Reading

References

Jan 1, 1987·Behaviour Research and Therapy·S RachmanC Lopatka
Jan 1, 1984·Behaviour Research and Therapy·P de Silva, S Rachman
Sep 1, 1996·Journal of Behavior Therapy and Experimental Psychiatry·P Muris, H Merckelbach
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·S E PetersenM E Raichle
Dec 24, 2002·The Journal of General Psychology·Frances K McSweeney, Samantha Swindell
Oct 7, 2003·Behaviour Research and Therapy·Timothy O RentzMichael J Telch
Oct 7, 2004·Learning & Memory·Francisco Sotres-BayonJoseph E LeDoux
Oct 22, 2004·Nature Reviews. Neuroscience·Stephen Maren, Gregory J Quirk
Dec 24, 2004·Cerebral Cortex·A M Clare Kelly, Hugh Garavan
Jan 18, 2006·Biological Psychiatry·Francisco Sotres-BayonJoseph E LeDoux
Mar 24, 2006·The European Journal of Neuroscience·Giuseppe BlasiVenkata S Mattay
Apr 6, 2006·Applied Neuropsychology·Aki JohansonLars Gustafson
Dec 13, 2006·Molecular Psychiatry·K M Myers, M Davis
Jan 9, 2007·NeuroImage·Daisuke TsuzukiIppeita Dan
Feb 20, 2007·Biological Psychology·Andrea HermannAnne Schienle
Feb 27, 2007·Journal of Anxiety Disorders·Naomi S Oliver, Andrew C Page
Aug 8, 2007·NeuroImage·Thomas StraubeWolfgang H R Miltner
Aug 21, 2007·Biological Psychiatry·Liesbet GoossensKoen R J Schruers
Sep 29, 2007·European Archives of Psychiatry and Clinical Neuroscience·Anne SchienleDieter Vaitl
Nov 17, 2007·Behaviour Research and Therapy·Michelle G CraskeAaron Baker
Apr 16, 2008·Clinical Psychology Review·Kate B Wolitzky-TaylorMichael J Telch
Aug 12, 2008·Behaviour Research and Therapy·Irena Milosevic, Adam S Radomsky
Sep 12, 2008·Clinical Psychology Review·Chris L ParrishMichel J Dugas
Mar 27, 2009·Psychiatry Research·Anne SchienleDieter Vaitl
Apr 29, 2009·Social Cognitive and Affective Neuroscience·Andrea HermannAnne Schienle
Nov 7, 2009·Journal of Behavior Therapy and Experimental Psychiatry·Brett J DeaconElizabeth A Nelson
Mar 9, 2010·Nature Neuroscience·Taiju AmanoDenis Paré
Jan 1, 2008·Social and Personality Psychology Compass·Jeffrey M SpielbergWendy Heller
Jul 27, 2010·Trends in Cognitive Sciences·David A Clark, Aaron T Beck
Aug 3, 2010·NeuroImage·Jan SchweckendiekRudolf Stark
Sep 28, 2010·Behaviour Research and Therapy·Heather K HoodCandice M Monson
Jan 25, 2011·NeuroImage·Sebastian OcklenburgChristian Beste
Mar 15, 2011·Behaviour Research and Therapy·Jennifer T SyBrett J Deacon
Mar 6, 2013·Cognitive Therapy and Research·Stefan G HofmannAngela Fang
May 29, 2013·Psychiatry and Clinical Neurosciences·Jonathan C IpserDan J Stein
Sep 17, 2013·PloS One·Irene MessinaRoberto Viviani
Nov 5, 2013·Clinical Psychology Review·Ioana R PodinăDaniel O David

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Citations

Sep 26, 2020·Scientific Reports·David RosenbaumAnn-Christine Ehlis
Jul 30, 2020·Scientific Reports·David RosenbaumAnn-Christine Ehlis
Jul 3, 2021·Brain Sciences·Henrikke Dybvik, Martin Steinert
Aug 10, 2021·Frontiers in Psychology·Sachiyo Ozawa

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Methods Mentioned

BETA
PCA

Clinical Trials Mentioned

NCT03653923

Software Mentioned

MATLAB

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