Cortical oxygenation suggests increased effort during cognitive inhibition in ecstasy polydrug users

Journal of Psychopharmacology
Carl A Roberts, C Montgomery

Abstract

It is understood that 3,4-methylenedioxymethamphetamine (ecstasy) causes serotonin dysfunction and deficits in executive functioning. When investigating executive function, functional neuroimaging allows the physiological changes underlying these deficits to be investigated. The present study investigated behavioural and brain indices of inhibition in ecstasy-polydrug users. Twenty ecstasy-polydrug users and 20 drug-naïve participants completed an inhibitory control task (Random Letter Generation (RLG)) while prefrontal haemodynamic response was assessed using functional near infrared spectroscopy (fNIRS). There were no group differences on background measures including sleep quality and mood state. There were also no behavioural differences between the two groups. However, ecstasy-polydrug users displayed significant increases in oxygenated haemoglobin (oxy-Hb) from baseline compared to controls at several voxels relating to areas of the inferior right medial prefrontal cortex, as well the right and left dorsolateral prefrontal cortex. Regression analysis revealed that recency of ecstasy use was a significant predictor of oxy-Hb increase at two voxels over the right hemisphere after controlling for alcohol and cannabis use ind...Continue Reading

References

May 1, 1990·The International Journal of Neuroscience·T Akerstedt, M Gillberg
May 1, 1966·The Quarterly Journal of Experimental Psychology·A D Baddeley
Feb 2, 2000·Neuroscience and Biobehavioral Reviews·K RubiaE T Bullmore
May 16, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·E Gouzoulis-MayfrankH Sass
Jun 1, 2000·British Journal of Psychology·M WareingP N Murphy
Sep 28, 2000·Trends in Neurosciences·J Duncan, A M Owen
Feb 19, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Liesbeth RenemanJan Booij
Dec 25, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hellmuth Obrig, Arno Villringer
Apr 23, 2003·Brain Research. Cognitive Brain Research·Jörg DaumannEuphrosyne Gouzoulis-Mayfrank
Sep 10, 2003·Trends in Cognitive Sciences·Clayton E. Curtis, Mark D'Esposito
Feb 26, 2004·Journal of Experimental Psychology. General·Naomi P Friedman, Akira Miyake
Mar 31, 2004·Trends in Cognitive Sciences·Adam R AronRussell A Poldrack
Jun 1, 2004·The Clinical Neuropsychologist·Carla Back-MadrugaRussell E Poland
Jun 29, 2004·Psychopharmacology·F Gerard MoellerPerry F Renshaw
Nov 6, 2004·British Journal of Psychology·John E FiskMichelle Wareing
Mar 4, 2005·Journal of Clinical and Experimental Neuropsychology·John E Fisk, Charles A Sharp
Nov 18, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael John MorganRobert David Rogers
Apr 1, 2006·Journal of Psychopharmacology·Liesbeth RenemanOnno Bakker
Aug 11, 2006·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Scott C BunceKambiz Pourrezaei
Apr 27, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gerry JagerNick F Ramsey
Jun 3, 2008·Human Psychopharmacology·Catharine Montgomery, John E Fisk
Jun 4, 2010·Human Psychopharmacology·Catharine MontgomeryAshok Jansari
Nov 26, 2010·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Hasan AyazBanu Onaral
Feb 23, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nina Bl UrbanMarc Laruelle
Mar 6, 2012·Human Psychopharmacology·Mark A WetherellAndrew B Scholey

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Citations

Mar 12, 2016·Psychological Medicine·C A RobertsC Montgomery
Jun 21, 2017·Human Psychopharmacology·Catharine MontgomeryCarl A Roberts
Apr 18, 2018·Global Advances in Health and Medicine : Improving Healthcare Outcomes Worldwide·Kristin K JergerAysenil Belger
Mar 16, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Carl A RobertsAntonio Verdejo-Garcia
Oct 9, 2021·Experimental Neurology·Catharine Montgomery, Carl A Roberts

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Methods Mentioned

BETA
infrared spectroscopy

Software Mentioned

fNIRSOFT
COBI

Related Concepts

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