DOI: 10.1101/501494Dec 19, 2018Paper

Cortical patterning of abnormal morphometric similarity in psychosis is associated with brain expression of schizophrenia related genes

BioRxiv : the Preprint Server for Biology
Sarah E MorganEdward T Bullmore

Abstract

Schizophrenia has been conceived as a disorder of brain connectivity but it is unclear how this network phenotype is related to the emerging genetics. We used morphometric similarity analysis of magnetic resonance imaging (MRI) data as a marker of inter-areal cortical connectivity in three prior case-control studies of psychosis: in total, N=185 cases and N=227 controls. Psychosis was associated with globally reduced morphometric similarity (MS) in all 3 studies. There was also a replicable pattern of case-control differences in regional MS which was significantly reduced in patients in frontal and temporal cortical areas, but increased in parietal cortex. Using prior brain-wide gene expression data, we found that the cortical map of case-control differences in MS was spatially correlated with cortical expression of a weighted combination of genes enriched for neurobiologically relevant ontology terms and pathways. In addition, genes that were normally over-expressed in cortical areas with reduced MS were significantly up-regulated in a prior post mortem study of schizophrenia. We propose that this combination of neuroimaging and transcriptional data provides new insight into how previously implicated genes and proteins, as wel...Continue Reading

Related Concepts

Biological Markers
Body Regions
Brain
Case-Control Studies
Cerebral Cortex
Gene Expression
Genes
Magnetic Resonance Imaging
Parietal Lobe
Psychotic Disorders

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