Cortical photothrombotic infarcts impair the recall of previously acquired memories but spare the formation of new ones

Stroke; a Journal of Cerebral Circulation
Kai DiederichJens Minnerup

Abstract

Despite a high incidence of poststroke dementia, there is no specific treatment for this condition. Because the evaluation of poststroke cognitive deficits in animal models of stroke is exceedingly challenging, the preclinical evaluation of candidate drugs is limited. We aimed to explore the impact of small cortical photothrombotic strokes on poststroke cognition, thereby assessing the suitability of this experimental stroke model for the investigation of cognitive impairment after stroke. Photothrombotic cortical infarcts were induced in 19 adult male Wistar rats. Nineteen sham-operated animals served as controls. Using the Morris water maze, we analyzed the impact of photothrombotic stroke on both the acquisition of new memories and the recall of previously acquired memories. The cylinder test, the adhesive tape removal test, and the rotarod test were performed to investigate sensorimotor deficits. Photothrombotic stroke significantly impaired the recall of previously acquired memories (P<0.05), whereas the acquisition of new memories remained largely intact. The analysis of the animals' swimming speed in the water maze and the rotarod test showed no confounding motor impairments after photothrombotic stroke. The adhesive tap...Continue Reading

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Citations

Oct 19, 2016·Molecular Neurobiology·Sreekala S NampoothiriRajanikant G Krishnamurthy
Apr 18, 2018·Annals of Neurology·Jens MinnerupWolf-Rüdiger Schäbitz
Apr 11, 2018·Stroke; a Journal of Cerebral Circulation·Lin Kooi OngJörgen Isgaard
Oct 1, 2017·Scientific Reports·Russell J ChanderNagaendran Kandiah

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