Cortical potentiation induced by calcitonin gene-related peptide (CGRP) in the insular cortex of adult mice.

Molecular Brain
Yinglu LiuMin Zhuo

Abstract

Recent studies demonstrate that calcitonin gene-related peptide (CGRP) plays critical roles in migraine. Immunohistochemistry and in situ hybridization studies have shown that CGRP and its receptors are expressed in cortical areas that are critical for pain perception including the anterior cingulate cortex (ACC) and insular cortex (IC). Recent studies reported that CGRP enhanced excitatory transmission in the ACC. However, little is known about the possible effect of CGRP on excitatory transmission in the IC. In the present study, we investigated the role of CGRP on synaptic transmission in the IC slices of adult male mice. Bath application of CGRP produced dose-dependent potentiation of evoked excitatory postsynaptic currents (eEPSCs). This potentiation was NMDA receptor (NMDAR) independent. After application of CGRP1 receptor antagonist CGRP8-37 or BIBN 4096, CGRP produced potentiation was significantly reduced. Paired-pulse facilitation was significantly decreased by CGRP, suggesting possible presynaptic mechanisms. Consistently, bath application of CGRP significantly increased the frequency of spontaneous and miniature excitatory postsynaptic currents (sEPSCs and mEPSCs). By contrast, amplitudes of sEPSCs and mEPSCs were n...Continue Reading

References

Aug 24, 2007·Clinical and Experimental Pharmacology & Physiology·D L Hay
Jul 18, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hui XuMin Zhuo
Nov 18, 2009·BMC Medicine·Till Sprenger, Peter J Goadsby
Sep 8, 2010·Nature Reviews. Neurology·Tony W HoPeter J Goadsby
Jan 14, 2011·Science Translational Medicine·Hansen WangMin Zhuo
Jul 20, 2011·Neurology·Eduardo E Benarroch
Nov 30, 2011·Expert Reviews in Molecular Medicine·Ann C Raddant, Andrew F Russo
May 31, 2013·Nature Reviews. Neuroscience·M Catherine BushnellLucie A Low
Aug 13, 2013·The European Journal of Neuroscience·Ming-Gang LiuMin Zhuo
Nov 12, 2013·Neuropeptides·Eric A Kaiser, Andrew F Russo
Oct 3, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shuang QiuMin Zhuo
Dec 20, 2014·Nature Reviews. Neuroscience·Ege T Kavalali
Nov 5, 2016·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·David BorsookLino Becerra
Feb 18, 2016·Trends in Neurosciences·Min Zhuo
Jun 17, 2016·Nature Reviews. Neuroscience·Tim V P BlissMin Zhuo
Oct 13, 2017·Cephalalgia : an International Journal of Headache·Lars Edvinsson, Karin Warfvinge
Oct 24, 2017·British Journal of Pharmacology·Debbie L HayChristopher S Walker
Nov 25, 2017·The New England Journal of Medicine·Peter J GoadsbyRobert A Lenz
Feb 23, 2018·The Journal of Headache and Pain·Timothy J SteinerZ Katsarava
Mar 22, 2018·Nature·Carlos A CamposRichard D Palmiter
Apr 29, 2018·Trends in Neurosciences·Richard D Palmiter
Aug 29, 2018·Handbook of Experimental Pharmacology·Graeme S Cottrell
Oct 12, 2018·Advances in Experimental Medicine and Biology·Min Zhuo
Sep 8, 2019·Journal of Neural Transmission·Min Zhuo

❮ Previous
Next ❯

Citations

Sep 17, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Xu-Hui LiMin Zhuo
Mar 15, 2021·The Journal of Comparative Neurology·Dake HuangJoel C Geerling

❮ Previous
Next ❯

Software Mentioned

Mini Analysis
GraphPad Prism
Clampfit
SPSS
Clampex

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.