Cortical reactivations of recent sensory experiences predict bidirectional network changes during learning.

Nature Neuroscience
Arthur U SugdenMark L Andermann

Abstract

Salient experiences are often relived in the mind. Human neuroimaging studies suggest that such experiences drive activity patterns in visual association cortex that are subsequently reactivated during quiet waking. Nevertheless, the circuit-level consequences of such reactivations remain unclear. Here, we imaged hundreds of neurons in visual association cortex across days as mice learned a visual discrimination task. Distinct patterns of neurons were activated by different visual cues. These same patterns were subsequently reactivated during quiet waking in darkness, with higher reactivation rates during early learning and for food-predicting versus neutral cues. Reactivations involving ensembles of neurons encoding both the food cue and the reward predicted strengthening of next-day functional connectivity of participating neurons, while the converse was observed for reactivations involving ensembles encoding only the food cue. We propose that task-relevant neurons strengthen while task-irrelevant neurons weaken their dialog with the network via participation in distinct flavors of reactivation.

References

Dec 24, 2002·Neuron·Albert K Lee, Matthew A Wilson
Dec 19, 2006·Nature Neuroscience·Daoyun Ji, Matthew A Wilson
Mar 16, 2007·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Jari SaramäkiJános Kertész
Mar 17, 2007·The Journal of Comparative Neurology·Quanxin Wang, Andreas Burkhalter
Jun 15, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rony PazDenis Paré
Nov 17, 2007·Science·David R EustonBruce L McNaughton
Feb 13, 2008·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·P ThévenazM Unser
Aug 19, 2008·Journal of Neuroscience Methods·Wael F Asaad, Emad N Eskandar
Jun 2, 2009·Nature Neuroscience·Adrien PeyracheFrancesco P Battaglia
Sep 15, 2009·Nature Neuroscience·Gabrielle GirardeauMichaël B Zugaro
Sep 26, 2009·Neuron·Eran A MukamelMark J Schnitzer
Jan 13, 2010·Neuron·Annabelle C Singer, Loren M Frank
Aug 7, 2010·Science·Tiziana Sacco, Benedetto Sacchetti
Jan 11, 2011·Nature Neuroscience·Arnulf B A GrafJ Anthony Movshon
Dec 16, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vincent BoninR Clay Reid
May 5, 2012·Science·Shantanu P JadhavLoren M Frank
Nov 23, 2012·Nature·N K LogothetisA Oeltermann
Jul 23, 2013·Nature·Tsai-Wen ChenDouglas S Kim
Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lorena DeukerNikolai Axmacher
Mar 29, 2014·Nature Neuroscience·Emmeke AartsSophie van der Sluis
Sep 10, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jae-eun Kang MillerRafael Yuste
Oct 3, 2014·Nature Protocols·Glenn J GoldeyMark L Andermann
Jun 16, 2015·Neuron·Matthew J McGinleyDavid A McCormick
Jun 26, 2015·Journal of Neurophysiology·José L ValdésJean-Marc Fellous
Jul 15, 2015·Nature Neuroscience·Hiroshi Makino, Takaki Komiyama
Aug 5, 2015·Cold Spring Harbor Perspectives in Biology·Larry R SquireRichard G Morris
Aug 16, 2015·Trends in Neurosciences·Laura A AthertonJack R Mellor
Oct 16, 2015·ELife·Stephen N GompertsMatthew A Wilson
Jan 18, 2016·Neuron·Eftychios A PnevmatikakisLiam Paninski
May 18, 2016·Nature Neuroscience·Nicolas MaingretMichaël Zugaro
Sep 17, 2016·Science·Arnaud MalvacheRosa Cossart
Dec 13, 2016·Nature Neuroscience·Gideon RothschildLoren M Frank
Jan 20, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vishnu P MurtyLila Davachi
Mar 10, 2017·Proceedings of the National Academy of Sciences of the United States of America·Matthew L LeavittJulio C Martinez-Trujillo
Apr 30, 2017·Current Opinion in Neurobiology·Igor Timofeev, Sylvain Chauvette
Aug 5, 2017·Annual Review of Neuroscience·David J Foster
Aug 22, 2017·Cell·Laura N DriscollChristopher D Harvey

❮ Previous
Next ❯

Citations

Jul 2, 2021·Cell·Matthew M NourRaymond J Dolan
Nov 14, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yaroslav Felipe Kalle KossioRaoul-Martin Memmesheimer

❮ Previous
Next ❯

Software Mentioned

MonkeyLogic
networkx
CellReg
Numpy
scipy
openEyes
Neuralynx
stats
Scanbox
TurboReg

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Adrenocortical carcinoma (ACC) is a rare malignancy of the adrenal cortex, associated with a generally dismal prognosis owing to its aggressive behavior. Here are the latest discoveries pertaining to this disease.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.

Related Papers

The American Review of Respiratory Disease
S Phillips
Journal of Burn Care & Research : Official Publication of the American Burn Association
Gianpiero GravanteAntonio Montone
Proceedings of the National Academy of Sciences of the United States of America
Jasmine HerszageNitzan Censor
© 2022 Meta ULC. All rights reserved