Cortical Reorganization of Peripheral Vision Induced by Simulated Central Vision Loss

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Nihong ChenBosco S Tjan

Abstract

When one's central vision is deprived, a spared part of the peripheral retina acts as a pseudofovea for fixation. The neural mechanisms underlying this compensatory adjustment remain unclear. Here we report cortical reorganization induced by simulated central vision loss. Human subjects of both sexes learned to place the target at an eccentric retinal locus outside their blocked visual field for object tracking. Before and after training, we measured visual crowding-a bottleneck of object identification in peripheral vision, using psychophysics and fMRI. We found that training led to an axis-specific reduction of crowding. The change of the crowding effect was reflected in the change of BOLD signal, as a release of cortical suppression in multiple visual areas starting as early as V1. Our findings suggest that the adult visual system is capable of reshaping its oculomotor control and sensory coding to adapt to impoverished visual input.SIGNIFICANCE STATEMENT By simulating central vision loss in normally sighted adults, we found that oculomotor training not only induces PRL, but also facilitates form processing in peripheral vision. As subjects learned to place the target at an eccentric retinal locus, "visual crowding"-the detr...Continue Reading

Citations

Nov 28, 2019·Acta Ophthalmologica·Therese Grønhøj KrarupMorten la Cour
Nov 23, 2021·Frontiers in Neuroscience·Marcello ManigliaAaron R Seitz

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