Cortical Responses to Vowel Sequences in Awake and Anesthetized States: A Human Intracranial Electrophysiology Study.

Cerebral Cortex
Kirill V NourskiMatthew I Banks

Abstract

Elucidating neural signatures of sensory processing across consciousness states is a major focus in neuroscience. Noninvasive human studies using the general anesthetic propofol reveal differential effects on auditory cortical activity, with a greater impact on nonprimary and auditory-related areas than primary auditory cortex. This study used intracranial electroencephalography to examine cortical responses to vowel sequences during induction of general anesthesia with propofol. Subjects were adult neurosurgical patients with intracranial electrodes placed to identify epileptic foci. Data were collected before electrode removal surgery. Stimuli were vowel sequences presented in a target detection task during awake, sedated, and unresponsive states. Averaged evoked potentials (AEPs) and high gamma (70-150 Hz) power were measured in auditory, auditory-related, and prefrontal cortex. In the awake state, AEPs were found throughout studied brain areas; high gamma activity was limited to canonical auditory cortex. Sedation led to a decrease in AEP magnitude. Upon LOC, there was a decrease in the superior temporal gyrus and adjacent auditory-related cortex and a further decrease in AEP magnitude in core auditory cortex, changes in th...Continue Reading

References

Mar 11, 1992·Electroencephalography and Clinical Neurophysiology·M SteinschneiderH G Vaughan
May 1, 1995·The Journal of the Acoustical Society of America·J HillenbrandK Wheeler
Jan 1, 1993·International Anesthesiology Clinics·G Plourde
Dec 1, 1999·The Journal of Comparative Neurology·M A HowardJ F Brugge
Aug 10, 2001·Journal of Neurophysiology·B H Gaese, J Ostwald
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·E AhissarM M Merzenich
Oct 29, 2002·Anesthesia and Analgesia·S Pockett, S M Tan
Mar 5, 2004·Acta Anaesthesiologica Scandinavica·H Viertiö-OjaP Meriläinen
Apr 26, 2006·Best Practice & Research. Clinical Anaesthesiology·G Plourde
May 23, 2007·Journal of Neuroscience Methods·Eric Maris, Robert Oostenveld
Jun 8, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Maria Ter-MikaelianMalcolm N Semple
Oct 17, 2007·Proceedings of the National Academy of Sciences of the United States of America·Matthew H DavisDavid K Menon
Apr 22, 2008·Nature Reviews. Neuroscience·Nicholas P Franks
May 28, 2009·Nature Neuroscience·Josef P Rauschecker, Sophie K Scott
Dec 17, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kirill V NourskiJohn F Brugge
Jun 4, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amber M Leaver, Josef P Rauschecker
Jul 8, 2010·Current Biology : CB·Timothy D GriffithsMatthew A Howard
Mar 9, 2011·Anesthesiology·UnCheol LeeGeorge A Mashour
Feb 9, 2012·Anesthesiology·Robert D SandersJamie W Sleigh
May 23, 2013·Anesthesiology·UnCheol LeeGeorge A Mashour
Oct 24, 2014·Frontiers in Systems Neuroscience·Aeyal RazMatthew I Banks
Nov 28, 2014·Journal of Clinical Monitoring and Computing·Sachiko MatsushitaKaneyuki Kawamae
Jan 21, 2015·Trends in Cognitive Sciences·Ina Bornkessel-SchlesewskyJosef P Rauschecker
Mar 3, 2015·Handbook of Clinical Neurology·Troy A Hackett
Mar 3, 2015·Handbook of Clinical Neurology·Kirill V Nourski, Matthew A Howard
Apr 22, 2015·Trends in Cognitive Sciences·Angela D Friederici, Wolf Singer
Jun 30, 2015·The European Journal of Neuroscience·Takahiro Noda, Hirokazu Takahashi
Dec 30, 2015·Journal of Neuroscience Methods·Christopher K Kovach, Phillip E Gander
Oct 7, 2016·Brain Structure & Function·Christophe DestrieuxIlyess Zemmoura
Sep 13, 2017·Laryngoscope Investigative Otolaryngology·Kirill V Nourski

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