Cortical Spreading Depression Denotes Concussion Injury

Journal of Neurotrauma
James BouleyNils Henninger

Abstract

Cortical spreading depression (CSD) has been described after moderate-to-severe traumatic brain injury (TBI). It is uncertain, however, whether CSD occurs after mild, concussive TBI and whether it relates to brain pathology and functional outcome. Male C57BL6/J mice (n = 62) were subjected to closed head TBI with a 25 g weight (n = 11), 50 g weight (n = 45), or sham injury (n = 6). Laser Doppler flowmetry and optical intrinsic signal imaging were used to determine cerebral blood flow dynamics after concussive CSD. Functional deficits were assessed at baseline, 2 h, 24 h, and 48 h. TUNEL and Prussian blue staining were used to determine cell death and presence of cerebral microbleeds at 48 h. No CSD was observed in mice subjected to a 25 g weight drop whereas 58.9% of mice subjected to a 50 g weight drop developed a CSD. Mice with concussive CSD displayed significantly greater numbers of apoptotic cell profiles in the ipsilesional hemisphere compared with mice without a CSD that underwent the same 50 g weight drop paradigm (p < 0.05, each). All investigated animals had at least one cerebral microbleed (range 1 to 24). Compared with mice without a CSD, mice with a CSD had significantly more microbleeds in the traumatized hemisphe...Continue Reading

References

Feb 1, 1982·Electroencephalography and Clinical Neurophysiology·M WestV Havlicek
Sep 5, 2002·Progress in Neurobiology·Nigel A Shaw
Mar 22, 2006·Journal of Biomechanics·Philip V BaylyGuy M Genin
Feb 1, 2008·The New England Journal of Medicine·Charles W HogeCarl A Castro
Jul 16, 2008·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Martin FabriciusMartin Lauritzen
Aug 29, 2009·Nature Protocols·Michael A FlierlEsther Shohami
Apr 12, 2011·Brain : a Journal of Neurology·Jed A HartingsUNKNOWN Co-Operative Study on Brain Injury Depolarizations
Oct 20, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Izumi YuzawaCenk Ayata
Nov 8, 2011·Lancet Neurology·Jed A HartingsUNKNOWN Co-Operative Study on Brain Injury Depolarisations
Oct 12, 2012·Brain Structure & Function·Huazheng LiangGeorge Paxinos
Nov 28, 2012·Lancet Neurology·Valery L FeiginUNKNOWN BIONIC Study Group
Mar 1, 2013·Neurology·Johannes WoitzikUNKNOWN COSBID study group
Mar 13, 2013·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Paul McCroryCharles H Tator
Nov 23, 2013·Brain : a Journal of Neurology·Jakob Møller HansenAndrew Charles
Aug 27, 2014·Brain : a Journal of Neurology·Jason M HinzmanJed A Hartings
May 23, 2015·Neuron·Jens P Dreier, Clemens Reiffurth
Jul 3, 2015·Physiological Reviews·Cenk Ayata, Martin Lauritzen
Dec 17, 2015·Journal of Neurotrauma·Patrick M KochanekFrank C Tortella
Dec 20, 2018·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Elisa BattistoniMarius V Peelen

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Citations

Jul 16, 2020·PLoS Computational Biology·Shixin XuHuaxiong Huang
Jul 8, 2020·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Mathieu LevesqueChristian Iorio-Morin
Nov 20, 2020·Cephalalgia : an International Journal of Headache·Todd J Schwedt
Apr 3, 2021·Frontiers in Neuroscience·Suna HuangYujie Chen
May 11, 2021·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Tamara L BakerSandy R Shultz
Aug 27, 2021·Neuroscience and Biobehavioral Reviews·Matthieu FaillotSuhan Senova

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