Cortical Spreading Depression Denotes Concussion Injury
Abstract
Cortical spreading depression (CSD) has been described after moderate-to-severe traumatic brain injury (TBI). It is uncertain, however, whether CSD occurs after mild, concussive TBI and whether it relates to brain pathology and functional outcome. Male C57BL6/J mice (n = 62) were subjected to closed head TBI with a 25 g weight (n = 11), 50 g weight (n = 45), or sham injury (n = 6). Laser Doppler flowmetry and optical intrinsic signal imaging were used to determine cerebral blood flow dynamics after concussive CSD. Functional deficits were assessed at baseline, 2 h, 24 h, and 48 h. TUNEL and Prussian blue staining were used to determine cell death and presence of cerebral microbleeds at 48 h. No CSD was observed in mice subjected to a 25 g weight drop whereas 58.9% of mice subjected to a 50 g weight drop developed a CSD. Mice with concussive CSD displayed significantly greater numbers of apoptotic cell profiles in the ipsilesional hemisphere compared with mice without a CSD that underwent the same 50 g weight drop paradigm (p < 0.05, each). All investigated animals had at least one cerebral microbleed (range 1 to 24). Compared with mice without a CSD, mice with a CSD had significantly more microbleeds in the traumatized hemisphe...Continue Reading
References
Mild traumatic brain injury in an insured population: subjective complaints and return to employment
Computational studies of strain exposures in neonate and mature rat brains during closed head impact
Distinctive anatomical and physiological features of migraine aura revealed by 18 years of recording
Synthesis of Findings, Current Investigations, and Future Directions: Operation Brain Trauma Therapy
Citations
Post-traumatic headache due to mild traumatic brain injury: Current knowledge and future directions.
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