Cortical structure and the risk for Alzheimer's disease: a bidirectional Mendelian randomization study.

Translational Psychiatry
Bang-Sheng WuJin-Tai Yu

Abstract

Progressive loss of neurons in a specific brain area is one of the manifestations of Alzheimer's disease (AD). Much effort has been devoted to investigating brain atrophy and AD. However, the causal relationship between cortical structure and AD is not clear. We conducted a bidirectional two-sample Mendelian randomization analysis to investigate the causal relationship between cortical structure (surface area and thickness of the whole cortex and 34 cortical regions) and AD risk. Genetic variants used as instruments came from a large genome-wide association meta-analysis of cortical structure (33,992 participants of European ancestry) and AD (AD and AD-by-proxy, 71,880 cases, 383,378 controls). We found suggestive associations of the decreased surface area of the temporal pole (OR (95% CI): 0.95 (0.9, 0.997), p = 0.04), and decreased thickness of cuneus (OR (95% CI): 0.93 (0.89, 0.98), p = 0.006) with higher AD risk. We also found a suggestive association of vulnerability to AD with the decreased surface area of precentral (β (SE): -43.4 (21.3), p = 0.042) and isthmus cingulate (β (SE): -18.5 (7.3), p = 0.011). However, none of the Bonferroni-corrected p values of the causal relationship between cortical structure and AD met th...Continue Reading

References

Nov 1, 1987·Neurobiology of Aging·P D Coleman, D G Flood
Jul 1, 1988·Archives of Neurology·D F BensonB D Snyder
Feb 1, 1994·Archives of Neurology·S E ArnoldG W Van Hoesen
Jul 1, 1996·Age and Ageing·S T O'KeeffeM Lye
Dec 21, 2002·BMJ : British Medical Journal·George Davey Smith, Shah Ebrahim
Apr 12, 2003·International Journal of Epidemiology·George Davey Smith, Shah Ebrahim
Mar 26, 2004·Cognitive, Affective & Behavioral Neuroscience·Tor D Wager, Edward E Smith
Sep 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg
Mar 14, 2007·Brain : a Journal of Neurology·An-Tao DuMichael W Weiner
Sep 22, 2007·Statistics in Medicine·Debbie A LawlorGeorge Davey Smith
Feb 8, 2008·Genes, Brain, and Behavior·O Wirths, T A Bayer
May 13, 2009·Brain : a Journal of Neurology·Frédéric PetersEric Salmon
Jul 21, 2009·European Radiology·Jasper D SluimerFrederik Barkhof
Sep 28, 2010·International Journal of Geriatric Psychiatry·C TunnardUNKNOWN AddNeuroMed Consortium
Oct 12, 2013·Genetic Epidemiology·Stephen BurgessSimon G Thompson
Oct 26, 2013·International Journal of Epidemiology·Marie-Jo A BrionPeter M Visscher
Feb 20, 2014·Progress in Neurobiology·Anders M FjellUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 30, 2014·Human Molecular Genetics·George Davey Smith, Gibran Hemani
Jun 8, 2015·International Journal of Epidemiology·Jack BowdenStephen Burgess
Feb 2, 2016·Ageing Research Reviews·Lorenzo PiniGiovanni B Frisoni
Feb 28, 2016·Lancet·Philip ScheltensWiesje Maria Van der Flier
Mar 11, 2016·The American Journal of Clinical Nutrition·Philip C HaycockGeorge Davey Smith
Sep 22, 2016·International Journal of Epidemiology·Jack BowdenGeorge Davey Smith
May 2, 2017·NeuroImage. Clinical·Silvio Ramos Bernardes da Silva FilhoJúlio César Moriguti
May 21, 2017·European Journal of Epidemiology·Stephen Burgess, Simon G Thompson
Nov 19, 2017·Neurology·Julie GonneaudGaël Chételat
Feb 20, 2018·Neurobiology of Aging·Konstantinos PoulakisEric Westman
Apr 2, 2018·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Raffaele CacciagliaUNKNOWN ALFA study
Sep 14, 2018·Frontiers in Neuroscience·Mark W LogueLindsay A Farrer
Sep 27, 2018·Nature Neuroscience·Hongjun FuKaren E Duff
Jan 2, 2019·Quantitative Imaging in Medicine and Surgery·Hongchun WeiUNKNOWN for Alzheimer’s Disease Neuroimaging Initiative*
Jul 18, 2019·JAMA Neurology·Niklas MattssonOskar Hansson
Apr 21, 2020·Journal of Alzheimer's Disease : JAD·Aku KaipainenSanna-Kaisa Herukka
May 24, 2020·Journal of Alzheimer's Disease : JAD·Nicolas NicastroJohn T O'Brien
Dec 17, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Vincent PlancheUNKNOWN the MEMENTO Study group.

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.