Cortical thickness and brain volumetric analysis in body dysmorphic disorder

Psychiatry Research
Sarah K MadsenJamie D Feusner

Abstract

Individuals with body dysmorphic disorder (BDD) suffer from preoccupations with perceived defects in physical appearance, causing severe distress and disability. Although BDD affects 1-2% of the population, the neurobiology is not understood. Discrepant results in previous volumetric studies may be due to small sample sizes, and no study has investigated cortical thickness in BDD. The current study is the largest neuroimaging analysis of BDD. Participants included 49 medication-free, right-handed individuals with DSM-IV BDD and 44 healthy controls matched by age, sex, and education. Using high-resolution T1-weighted magnetic resonance imaging, we computed vertex-wise gray matter (GM) thickness on the cortical surface and GM volume using voxel-based morphometry. We also computed volumes in cortical and subcortical regions of interest. In addition to group comparisons, we investigated associations with symptom severity, insight, and anxiety within the BDD group. In BDD, greater anxiety was significantly associated with thinner GM in the left superior temporal cortex and greater GM volume in the right caudate nucleus. There were no significant differences in cortical thickness, GM volume, or volumes in regions of interest between ...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Oct 1, 1977·The British Journal of Psychiatry : the Journal of Mental Science·R P Snaith
Jan 21, 1995·BMJ : British Medical Journal·J M Bland, D G Altman
Jan 20, 1998·The American Journal of Psychiatry·J L EisenS A Rasmussen
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Sep 30, 2000·Journal of the International Neuropsychological Society : JINS·T DeckersbachM A Jenike
Aug 3, 2001·Nature Reviews. Neuroscience·H O Karnath
Sep 8, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MazziottaB Mazoyer
Jan 1, 1959·The British Journal of Medical Psychology·M HAMILTON
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Nov 18, 2004·Psychiatry Research·Stephen P WhitesideJonathan S Abramowitz
May 26, 2007·Human Brain Mapping·Yong-Wook ShinJun Soo Kwon
Dec 7, 2007·Archives of General Psychiatry·Jamie D FeusnerSusan Bookheimer
Jan 5, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Janet B W Williams, Kenneth A Kobak
Sep 18, 2008·Neuroreport·Veena M NarayanPhilip R Szeszko
Mar 31, 2009·Psychiatry Research·Jamie D FeusnerSusan Bookheimer
Oct 23, 2009·Journal of Affective Disorders·Murad AtmacaM Gurkan Gurok
Feb 4, 2010·Archives of General Psychiatry·Jamie D FeusnerSusan Bookheimer
Jun 10, 2010·Depression and Anxiety·Katharine A PhillipsJames Leckman
May 12, 2011·Psychological Medicine·J D FeusnerT D Moody
Jan 19, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Takashi NakamaeKenji Fukui
Oct 17, 2012·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Simone KühnNorbert Kathmann
Feb 5, 2013·Psychiatry Research·Jamie D FeusnerAlex D Leow
Jan 7, 2014·The Primary Care Companion to CNS Disorders·Amir MufaddelMohammad Jafferany
Feb 6, 2014·The Australian and New Zealand Journal of Psychiatry·Ben BuchananDavid Castle

❮ Previous
Next ❯

Citations

Jan 2, 2019·Pilot and Feasibility Studies·Francesca BeilharzSusan L Rossell
Dec 29, 2020·Neuroscience and Biobehavioral Reviews·Maria Gloria RossettiPaolo Brambilla
Oct 12, 2017·Neuroscience and Biobehavioral Reviews·Sally A GraceSusan L Rossell

❮ Previous
Next ❯

Related Concepts

Related Feeds

Body Dysmorphic Disorder

Body dysmorphic disorder is an intense preoccupation with an imagined defect in ones physical appearance. It can be a severely impairing disorder and is common among patients with obsessive-compulsive disorder. Discover the latest research on body dysmorphic disorder here.