Cortical thickness in regions of frontal and temporal lobes is associated with responsiveness to cognitive remediation therapy in schizophrenia

Schizophrenia Research
Rafael PenadésCarme Junqué

Abstract

Despite the evidence for the efficacy of cognitive remediation therapy (CRT) in patients with schizophrenia, comparatively little is known about the potential predictors of good treatment response. We tried to determine whether improvement in cognition following CRT is positively associated with baseline cortical thickness (CTh) or baseline clinical symptoms level or baseline cognitive performance. The current work uses data collected in a previous study (Penadés et al., 2013) in which a CRT program was investigated through a controlled randomized trial (NCT 01318850) with three groups: patients receiving cognitive treatment, patients receiving a different psychological intervention as an active and a healthy control groups (HC). CTh was estimated from the T1-weighted MRIs using the FreeSurfer software. We found that CRT responsiveness was associated with baseline measures of cortical thickness in the frontal and temporal lobes. Positive changes in non-verbal memory were associated with greater initial thickness in cortical regions involving left superior frontal, left caudal middle frontal, left precuneus and paracentral; superior frontal, right caudal middle frontal gyrus and pars opercularis. Additionally, uncorrected data a...Continue Reading

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Citations

Jun 11, 2019·The Australian and New Zealand Journal of Psychiatry·Maree P ReserSusan L Rossell
May 14, 2020·World Journal of Psychiatry·Alexandre González-RodríguezMary V Seeman
Jan 12, 2021·Schizophrenia Research·Benedetta SeccomandiMatteo Cella
Mar 5, 2021·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Silvia AmorettiUNKNOWN PEPs Group
Dec 13, 2019·Schizophrenia Research. Cognition·Benedetta SeccomandiMatteo Cella
Apr 18, 2021·Psychiatry Research. Neuroimaging·Ian S RamsayDaniel H Mathalon

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