Cortical thickness, stance control, and arithmetic skill: An exploratory study in premanifest Huntington disease

Parkinsonism & Related Disorders
Lorenzo NanettiCaterina Mariotti

Abstract

Huntington disease (HD) is an inherited neurodegenerative disorder most commonly manifesting in adulthood. Identification of biomarkers tracking neurodegeneration before the onset of motor symptoms is important for future interventional studies. Our study aimed to contribute in the phenotypic characterization of the premanifest HD phase. 28 premanifest subjects (preHD), 25 age-matched controls, and 12 manifest HD patients were enrolled for the study. The participants underwent a multimodal protocol including cognitive evaluations, arithmetic ability test, posturography, composite cerebellar functional test (CCFS), and brain 3T-MRI. PreHD were divided at the group median for predicted years to expected onset into "far-from-onset" (>15 years, PreHD-far), and "close-to-onset" (≤15 years, preHD-close). Basal ganglia volumes and cortical thickness were computed using FreeSurfer. PreHD-close showed significantly lower scores than controls in Symbol Digit Modalities Test (p = 0.017), Arithmetic subtraction task (p = 0.04), and MMSE (p < 0.006). At posturography, preHD-close showed increased sway velocity (<0.04) and distance (p < 0.02) compared to controls. PreHD-close had reduced striatum and globus pallidus volumes and left occipita...Continue Reading

Citations

Jul 21, 2020·Movement Disorders : Official Journal of the Movement Disorder Society·Douglas R Langbehn, Steven Hersch
Jul 1, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·L PiniC Jacquemot
Aug 15, 2020·Annals of Clinical and Translational Neurology·Johnny LoTravis M Cruickshank
Jan 23, 2019·Frontiers in Neural Circuits·Galit Saar, Alan P Koretsky
Jun 6, 2020·Antioxidants & Redox Signaling·Lígia Fão, Ana Cristina Rego
Nov 10, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Ignacio Aracil-BolañosJaime Kulisevsky

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxias (MDS)

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Ataxia

Ataxia is a neurological condition characterized by lack of voluntary coordination of muscle movements including loss of coordination, balance, and speech. Discover the latest research on ataxia here.