Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO.

Molecular and Cellular Biology
Wei ZhangJong-Sun Kang

Abstract

CDO is a cell surface immunoglobulin superfamily member that positively regulates myogenic differentiation in vitro and in vivo and signals to posttranslationally activate myogenic basic helix-loop-helix (bHLH) transcription factors. The Cdo gene is also expressed in the dorsal aspect and midline structures of the developing central nervous system, and mice lacking CDO on the C57BL/6 background display holoprosencephaly with approximately 80% penetrance, resulting in perinatal lethality. We report here that a fraction of Cdo-/- mice from this background have additional defects in brain development, including hydrocephalus and cortical thinning. Primary neural progenitor cultures from E14.5 Cdo-/- mutants display reduced proliferation, which may underlie the thinning. The cortical preplate and cortices of mutant animals also show reduced staining for beta-tubulin III, indicating defective neuronal differentiation. CDO levels are strongly increased in cultured C17.2 neuronal precursor cells stimulated to differentiate; modulation of CDO levels in these cells by overexpression or interfering RNA approaches enhances or diminishes differentiation, respectively. Cotransfection of CDO enhances the activity of the neurogenic bHLH facto...Continue Reading

References

Jan 1, 1990·Journal of Medical Genetics·H BachmanW Salahi
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H WeintraubA D Miller
Sep 1, 1995·Trends in Neurosciences·V S CavinessR S Nowakowski
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·T TakahashiV S Caviness
Jan 20, 1997·The Journal of Comparative Neurology·D J PriceK Gillies
Feb 1, 1997·Current Opinion in Neurobiology·J E Lee
Oct 24, 1998·The Journal of Cell Biology·J S KangR S Krauss
Feb 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·B SiminszkyR E Dewey
Sep 16, 1999·American Journal of Human Genetics·I VisapääL Peltonen
Oct 21, 1999·Molecular Genetics and Metabolism·D E Wallis, M Muenke
Aug 3, 2000·Human Mutation·D Wallis, M Muenke
Sep 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P J MulieriR S Krauss
Sep 15, 2000·Current Opinion in Neurology·S L KinsmanJ S Hahn
Feb 13, 2001·Brain Research·B RolfU Bartsch
Mar 10, 2001·Microscopy Research and Technique·J M Pérez-FígaresE M Rodríguez
Nov 1, 2001·Nature Neuroscience·E S Monuki, C A Walsh
Jul 3, 2002·Nature Reviews. Neuroscience·Nicolas BertrandFrançois Guillemot
Mar 7, 2003·Current Biology : CB·Francesca Cole, Robert S Krauss
Mar 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jong-Sun KangRobert S Krauss
Jul 10, 2003·Neuron·Sarah E RossCharles D Stiles
Nov 3, 2004·The Journal of Cell Biology·Jong-Sun KangRobert S Krauss
Mar 8, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Rodney AllanMark Dexter
Apr 22, 2005·Human Molecular Genetics·Lisa MeeLeena Peltonen

❮ Previous
Next ❯

Citations

Feb 27, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ji-Eun OhJong-Sun Kang
Apr 16, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Irum NaureenJaleel A Miyan
Aug 15, 2014·Stem Cell Research·Yu-Rim KwonJong-Sun Kang
Sep 17, 2009·The FEBS Journal·Wei ZhangJong-Sun Kang
Mar 9, 2011·Developmental Biology·Yanmei TianAudrey Minden
Aug 19, 2009·Developmental Cell·Olga OssipovaSergei Y Sokol
Nov 19, 2008·The Journal of Biological Chemistry·Eun Kyung LeeJeung-Whan Han
Jul 9, 2014·Nature Communications·Marcos Julián CardozoPaola Bovolenta
May 5, 2012·Chembiochem : a European Journal of Chemical Biology·Ming LiKwok-Fai Lau
Feb 6, 2017·Proceedings of the National Academy of Sciences of the United States of America·Myong-Ho JeongJong-Sun Kang
Nov 7, 2017·Frontiers in Molecular Neuroscience·Héctor GálvezGina Abelló
Aug 29, 2018·Brain Plasticity·Odessa R Yabut, Samuel J Pleasure
Jul 8, 2008·Acta Biochimica Et Biophysica Sinica·Jingwu Xie
Nov 13, 2020·Frontiers in Cell and Developmental Biology·Julien FerentFiona Francis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.