Cortical thinning and progressive cortical porosity in female patients with systemic lupus erythematosus on long-term glucocorticoids: a 2-year case-control study

Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
T Y ZhuL-S Tam

Abstract

In this study, we characterized longitudinal changes of volumetric bone mineral density and cortical and trabecular microstructure at the distal radius using HR-pQCT in female systemic lupus erythematosus (SLE) patients on long-term glucocorticoids. Cortical thinning and increased cortical porosity are the major features of longitudinal microstructural deterioration in SLE patients. The study aims to characterize longitudinal changes of volumetric bone mineral density (vBMD) and bone microstructure at distal radius in female systemic lupus erythematosus (SLE) patients on long-term glucocorticoids. This 2-year case-control study consisted of 166 premenopausal subjects (75 SLE patients and 91 controls) and 79 postmenopausal subjects (44 SLE patients and 35 controls). We obtained areal BMD (aBMD) by dual-energy X-ray absorptiometry at multiple skeletal sites and indices of vBMD and microstructure at distal radius by high-resolution peripheral quantitative computed tomography (HR-pQCT) at baseline, 12 and 24 months. In either premenopausal or postmenopausal subjects, changes in aBMD did not differ between patients and controls except that decrease in aBMD at total hip at 24 months in premenopausal patients was significantly higher....Continue Reading

References

Jan 1, 1984·Metabolic Bone Disease & Related Research·N M Keshawarz, R R Recker
Aug 16, 2000·Arthritis and Rheumatism·A Zonana-NacachM Petri
Jul 25, 2003·The New England Journal of Medicine·Henrik G AhlborgMagnus K Karlsson
Oct 28, 2003·Clinical Rheumatology·M BoyanovP Popivanov
Jun 3, 2005·Clinical Orthopaedics and Related Research·Leung Kim HungLing Qin
Jul 20, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·H S LynnP C Leung
Sep 29, 2005·The Journal of Clinical Endocrinology and Metabolism·Stephanie BoutroyPierre D Delmas
May 26, 2006·The New England Journal of Medicine·Ego Seeman, Pierre D Delmas
Dec 22, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth Sornay-RenduPierre D Delmas
Feb 20, 2007·Lancet·David P D'CruzGraham R V Hughes
May 22, 2007·Journal of Orthopaedic Surgery and Research·Ling QinPingchung Leung
Dec 7, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Galateia J KazakiaSharmila Majumdar
Feb 19, 2008·Calcified Tissue International·Hiroshi KajiToshitsugu Sugimoto
Jul 31, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Laurence VicoChristian Alexandre
Dec 31, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth Sornay-RenduPierre D Delmas
Mar 12, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ego SeemanJose Zanchetta
Jun 22, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Andrew J BurghardtSharmila Majumdar
Jan 4, 2012·Arthritis Care & Research·Irene E M Bultink
Oct 12, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J JacobsI E M Bultink
Oct 24, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tracy Y ZhuLai-Shan Tam
Oct 30, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·X L TangL-S Tam
Dec 12, 2012·Nature Reviews. Rheumatology·Anselm MakChak-Sing Lau
Dec 4, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·I E M BultinkF de Vries
Mar 7, 2014·Nature Reviews. Rheumatology·Piet GeusensJoop van den Bergh
Jul 6, 2014·The Journal of Rheumatology·Tracy Y ZhuLai-Shan Tam

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Citations

Apr 14, 2016·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Catherine OkoukoniJeffrey S Willey
Sep 14, 2017·Calcified Tissue International·Irene E M Bultink
Jun 13, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Tracy Y ZhuLing Qin
Dec 12, 2019·Lupus·J NordqvistH Carlsten
Apr 29, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M M Sampaio-BarrosR M R Pereira
Dec 22, 2017·Annals of the New York Academy of Sciences·Adele L Boskey, Laurianne Imbert
May 24, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J P van den BerghR Chapurlat

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