Cortical thinning in bipolar disorder and schizophrenia.

Schizophrenia Research
Christian KnöchelViola Oertel-Knöchel

Abstract

Although schizophrenia (SZ) and bipolar disorder (BD) share some clinical features such as psychotic symptoms and cognitive dysfunctions, little is known about possible pathophysiological similarities between both diseases. Therefore, we investigated the potential topographical overlap and segregation of cortical thickness abnormalities in SZ and BD patients. We analyzed 3D-anatomical magnetic resonance imaging datasets with the FreeSurfer 5.1.0 software to examine cortical thickness and volumes in three groups of participants: n=34 BD patients, n=32 SZ patients and n=38 healthy controls. We observed similar bilateral cortical thickness reductions in BD and SZ patients predominantly in the pars opercularis of the inferior frontal gyrus and in the anterior and posterior cingulate. We also found disease-specific cortical reductions in the orbitofrontal cortex for BD patients and in dorsal frontal and temporal areas for SZ. Furthermore, inferior frontal gyrus cortical thinning was associated with deficits in psychomotor speed and executive functioning in SZ patients and with age at onset in both groups. Our findings support the hypothesis that thinning of the frontal cortex may represent a biological feature shared by both disease...Continue Reading

References

Aug 1, 1988·Journal of Clinical and Experimental Neuropsychology·R M ReitanD Wolfson
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Nov 10, 2000·Lancet·G J MooreH K Menji
Mar 30, 2001·Cerebral Cortex·Y HirayasuR W McCarley
Mar 22, 2002·NeuroImage·Christopher R GenoveseThomas Nichols
Apr 18, 2002·Biological Psychiatry·J Douglas BremnerDennis S Charney
Oct 25, 2002·The British Journal of Clinical Psychology·Anthony P MorrisonSarah Nothard
Jun 26, 2003·The Journal of Clinical Psychiatry·Scott W Woods
Sep 10, 2003·Archives of General Psychiatry·Gina R KuperbergBruce Fischl
Jun 29, 2004·NeuroImage·F SégonneB Fischl
Mar 3, 2005·The American Journal of Psychiatry·Nancy C AndreasenDaniel R Weinberger
May 3, 2005·The British Journal of Psychiatry : the Journal of Mental Science·Nick Craddock, Michael J Owen
Jan 18, 2006·Bipolar Disorders·In Kyoon LyooPerry F Renshaw
Jul 10, 2007·Biological Psychiatry·T William J MoorheadAndrew M McIntosh
Feb 5, 2008·The American Journal of Psychiatry·Mary L PhillipsDavid J Kupfer
May 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Alex FornitoChristos Pantelis
May 6, 2009·Archives of General Psychiatry·Aaron L GoldmanAndreas Meyer-Lindenberg
May 29, 2009·Journal of Psychiatric Research·Unn Kristin HaukvikIngrid Agartz
Jan 15, 2010·Schizophrenia Research·Ian Ellison-Wright, Ed Bullmore
Jan 21, 2010·Psychological Medicine·J Moncrieff, J Leo
Feb 2, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Nick Craddock, Michael J Owen
Jul 9, 2010·Biological Psychiatry·Lars M RimolIngrid Agartz
Mar 26, 2011·Schizophrenia Bulletin·Stefan EhrlichScott R Sponheim
Jan 17, 2012·Neuron·David E J Linden
Jan 28, 2012·Biological Psychiatry·Lars M RimolAnders M Dale
Apr 5, 2012·Archives of General Psychiatry·Hilleke E Hulshoff PolRené S Kahn
May 29, 2012·Bipolar Disorders·Danella M HafemanMary L Phillips
Aug 3, 2014·Schizophrenia Research·Joost JanssenManuel Desco
Jan 13, 2015·Journal of Affective Disorders·Viola Oertel-KnöchelChristian Knöchel

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Citations

Jun 27, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yong-Ku Kim, Kyoung-Sae Na
Nov 29, 2017·Scientific Reports·Thiago Monteiro Paiva FernandesNatanael Antonio Santos
Oct 15, 2019·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Thomas M PiaseckiWendy S Slutske
Apr 24, 2018·Schizophrenia Bulletin·Sungkean KimSeung-Hwan Lee
Jul 12, 2018·International Journal of Bipolar Disorders·Douglass GodwinDaniel Mamah
Aug 24, 2016·European Archives of Psychiatry and Clinical Neuroscience·Christian KnöchelViola Oertel-Knöchel
Mar 21, 2018·European Archives of Psychiatry and Clinical Neuroscience·Cathrin RohlederDusan Hirjak
Apr 13, 2021·Frontiers in Psychiatry·Jun ZhongNi Fan
Jun 8, 2021·Schizophrenia Bulletin·James A KarantonisTamsyn E Van Rheenen
Aug 13, 2021·Social Psychiatry and Psychiatric Epidemiology·Janina I SchweigerHeike Tost
Aug 20, 2021·Schizophrenia Bulletin·Brett A ClementzCarol A Tamminga

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