Cortical thinning in epilepsy patients with postictal generalized electroencephalography suppression

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
Y TangD Zhou

Abstract

The aim was to investigate the brain microstructural abnormalities in epilepsy patients with postictal generalized electroencephalographic suppression (PGES) using a cortical surface-based analysis. According to the video-electroencephalography records of epilepsy patients with generalized convulsive seizures, 30 patients with PGES (PGES+) and 21 patients without PGES (PGES-) were recruited. High-resolution T1-weighted images were acquired from each patient and 30 matched healthy control subjects. Cortical thickness was compared amongst the three groups using FreeSurfer software. Patients with PGES showed reduced cortical thickness in the right paracentral lobule, inferior parietal lobule, supramarginal gyrus and middle temporal lobe compared with patients without PGES. In relation to healthy control subjects, the PGES+ group presented reduced cortical thickness in the right superior parietal lobule and supramarginal gyrus, whilst the PGES- group presented reduced cortical thickness in the left precuneus, precentral gyrus, lateral occipital gyrus, parahippocampal gyrus, superior parietal lobule and right caudal middle frontal gyrus. Patients with PGES exhibited characteristic brain microstructural abnormalities, corroborating t...Continue Reading

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Citations

Jan 30, 2019·Current Opinion in Neurology·Philippe RyvlinSamden D Lhatoo
Apr 10, 2020·Expert Review of Neurotherapeutics·Max Christian PenselRainer Surges
Aug 12, 2020·Brain : a Journal of Neurology·Mariasavina SeverinoAndrea Rossi
Jan 4, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Majdi JberMohammad-Reza Nazem-Zadeh
Jan 26, 2021·Epilepsy & Behavior : E&B·Aileen McGonigalEric Guedj

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