Cortico-motoneuronal excitation of three hand muscles determined by a novel penta-stimulation technique

Brain : a Journal of Neurology
Ulf ZiemannFrank Meintzschel

Abstract

The cortico-motoneuronal system (CMS), i.e. the monosynaptic projection from primary motor cortex to motoneurons in lamina IX of the spinal cord is, among all mammals, best developed in humans. Increasing evidence suggests that the CMS is crucially important for skilled individuated finger movements. Little is known about to what extent the strength of the CMS differs between hand muscles. Here we measured CMS excitation to the first dorsal interosseus (FDI), abductor pollicis brevis (APB) and abductor digiti minimi (ADM) muscles in healthy subjects by using a novel penta-stimulation technique (PST) and single motor unit (SMU) recordings. The PST is an extension of the triple-stimulation technique. It applies two additional supramaximal electrical stimuli at the wrist to the 'peripheral nerve of no interest' (in the case of the FDI and ADM the median nerve, in the case of the APB the ulnar nerve) to collide with the descending volleys in that nerve elicited by transcranial magnetic stimulation of motor cortex and electrical stimulation of Erb's point. This eliminates volume conduction from neighbouring muscles innervated by the nerve of no interest and, therefore, allows accurate determination of the PST response. The PST respo...Continue Reading

Citations

Dec 6, 2005·Experimental Brain Research·Zhen NiTatsuya Kasai
Apr 19, 2008·Experimental Brain Research·Markus KoflerLeopold Saltuari
May 26, 2005·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Tihomir V Ilić, Stevan Petković
Apr 30, 2011·Vojnosanitetski pregled. Military-medical and pharmaceutical review·Tihomir V IlićAleksandra Dominović-Kovacević
Dec 8, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Robert ChenUlf Ziemann
Mar 13, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Manyoel LimChun Kee Chung
Oct 29, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Makoto TakahashiTatsuya Kasai
Dec 10, 2016·Journal of Motor Behavior·Hikari KirimotoHideaki Onishi
Jun 19, 2017·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·José Manuel MatamalaMatthew C Kiernan

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