Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness

Frontiers in Systems Neuroscience
Peter FettesJonathan Downar

Abstract

Corticostriatal circuits through the orbitofrontal cortex (OFC) play key roles in complex human behaviors such as evaluation, affect regulation and reward-based decision-making. Importantly, the medial and lateral OFC (mOFC and lOFC) circuits have functionally and anatomically distinct connectivity profiles which differentially contribute to the various aspects of goal-directed behavior. OFC corticostriatal circuits have been consistently implicated across a wide range of psychiatric disorders, including major depressive disorder (MDD), obsessive compulsive disorder (OCD), and substance use disorders (SUDs). Furthermore, psychiatric disorders related to OFC corticostriatal dysfunction can be addressed via conventional and novel neurostimulatory techniques, including deep brain stimulation (DBS), electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), and transcranial direct current stimulation (tDCS). Such techniques elicit changes in OFC corticostriatal activity, resulting in changes in clinical symptomatology. Here we review the available literature regarding how disturbances in mOFC and lOFC corticostriatal functioning may lead to psychiatric symptomatology in the aforementioned disorders, and h...Continue Reading

References

Feb 15, 1976·The Journal of Comparative Neurology·M B CarpenterR Kim
Dec 3, 1976·Brain Research·D A Chavis, D N Pandya
May 1, 1991·The American Journal of Psychiatry·N D VolkowA Hoff
Mar 1, 1989·Archives of General Psychiatry·L R BaxterR M Sumida
Jan 1, 1986·Annual Review of Neuroscience·G E AlexanderP L Strick
Dec 1, 1988·The American Journal of Psychiatry·L R BaxterL Fairbanks
Jun 15, 1985·The Journal of Comparative Neurology·I A IlinskyP S Goldman-Rakic
Aug 1, 1972·Experimental Neurology·B Jones, M Mishkin
Jan 1, 1981·Experimental Brain Research·D N PandyaM M Mesulam
Aug 1, 1983·The American Journal of Psychiatry·J FawcettD Hedeker
Oct 8, 1993·The Journal of Comparative Neurology·J F Bates, P S Goldman-Rakic
Sep 15, 1994·Biological Psychiatry·F BiverF Lotstra
Aug 1, 1994·Brain : a Journal of Neurology·A Pascual-LeoneM Hallett
Aug 1, 1993·Archives of Neurology·J L Cummings
Aug 1, 1995·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·J M StapletonE D London
Apr 1, 1996·Current Opinion in Neurobiology·R A Wise
Jul 1, 1997·The Journal of Neuropsychiatry and Clinical Neurosciences·M S MegaP Malloy
Aug 1, 1997·Archives of General Psychiatry·A I Leshner
Oct 10, 1998·The Journal of Comparative Neurology·T A HackettJ H Kaas
Nov 20, 1998·Biological Psychiatry·C M Gullion, A J Rush
Jun 11, 1999·The Journal of Clinical Psychiatry·J L EisenS A Rasmussen
Mar 24, 2000·Cerebral Cortex·C CavadaF Reinoso-Suárez
Mar 24, 2000·Cerebral Cortex·A BecharaA R Damasio
Mar 24, 2000·Cerebral Cortex·E D LondonA Weinstein
Sep 15, 2000·The Psychiatric Clinics of North America·L M Koran
Sep 23, 2000·The Journal of Neuropsychiatry and Clinical Neurosciences·R C ChackoR G Harper
Jan 3, 2001·Nature Neuroscience·J O'DohertyC Andrews
Feb 7, 2001·The American Journal of Psychiatry·M S NoblerJ J Mann
Apr 3, 2001·The Journal of ECT·M E HenryW Z Potter
Aug 28, 2001·Brain : a Journal of Neurology·D M SmallM Jones-Gotman

❮ Previous
Next ❯

Citations

Mar 11, 2018·The Journal of Comparative Neurology·Monika J M Murphy, Ariel Y Deutch
Mar 7, 2018·CNS Neuroscience & Therapeutics·Fei-Fei ZhangQi-Yong Gong
Apr 6, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Peter ZhukovskyJeffrey W Dalley
Jul 7, 2019·European Archives of Psychiatry and Clinical Neuroscience·Mike M SchmitgenRobert C Wolf
Jun 20, 2019·Journal of Psychopharmacology·Natasha E WadeJoanna Jacobus
Aug 21, 2018·The International Journal of Neuropsychopharmacology·Beata R GodlewskaCatherine J Harmer
Dec 11, 2019·Journal of Neuroscience Research·Ellen P WoonShannon L Gourley
Sep 17, 2019·European Psychiatry : the Journal of the Association of European Psychiatrists·Rémy BationJerome Brunelin
Jan 23, 2020·The American Journal of Psychiatry·Lisa M McTeagueAmit Etkin
Nov 7, 2019·Journal of Neuroscience Research·Melissa Malvaez
Nov 1, 2017·The International Journal of Neuropsychopharmacology·Gabriele Sachs, Andreas Erfurth
Aug 21, 2020·Proceedings of the National Academy of Sciences of the United States of America·Guoping FengJohn H Morrison
Sep 16, 2017·Frontiers in Neuroscience·Nayeli HuidobroElias Manjarrez
Apr 11, 2018·F1000Research·Kevin HongEric Hollander
Jun 15, 2018·Frontiers in Human Neuroscience·Xiaoqin DuanWei Yang
Sep 5, 2020·Nature·Abhishek BanerjeeFritjof Helmchen
Apr 30, 2019·Nutritional Neuroscience·Jennifer R SadlerKyle S Burger
Nov 11, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Grace R JacobsStephanie H Ameis
Nov 12, 2020·Acta Neurologica Scandinavica·Shweta PrasadPramod Kumar Pal
Nov 10, 2020·International Journal of Neural Systems·Sisi JiangCheng Luo
Oct 25, 2020·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Pamela DeRosse, Anita D Barber
Jan 8, 2021·Alzheimer's Research & Therapy·Adeline Su Lyn NgJuan Helen Zhou
Jul 4, 2021·NeuroImage. Clinical·Laura Finlayson-ShortChristopher Davey
Jul 19, 2021·Psychiatry Research. Neuroimaging·Gereon Johannes SchnellbächerMikhail Votinov
Jul 24, 2021·Cerebral Cortex Communications·Cassandra MaLaura A Bradfield

❮ Previous
Next ❯

Methods Mentioned

BETA
pharmacotherapy
cognitive behavioral therapy

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

© 2022 Meta ULC. All rights reserved