Cortico-subcortical organization of language networks in the right hemisphere: an electrostimulation study in left-handers

Neuropsychologia
Hugues DuffauP Gatignol

Abstract

We have studied the configuration of the cortico-subcortical language networks within the right hemisphere (RH) in nine left-handers, being operated on while awake for a cerebral glioma. Intraoperatively, language was mapped using cortico-subcortical electrostimulation, to avoid permanent deficit. In frontal regions, cortical stimulation elicited articulatory disorders (ventral premotor cortex), anomia (dorsal premotor cortex), speech arrest (pars opercularis), and semantic paraphasia (dorsolateral prefrontal cortex). Insular stimulation generated dysarthria, parietal stimulation phonemic paraphasias, and temporal stimulation semantic paraphasias. Subcortically, the superior longitudinal fasciculus (inducing phonological disturbances when stimulated), inferior occipito-frontal fasciculus (eliciting semantic disturbances during stimulation), subcallosal fasciculus (generating control disturbances when stimulated), and common final pathway (inducing articulatory disorders during stimulation) were identified. These cortical and subcortical structures were preserved, avoiding permanent aphasia, despite a transient immediate postoperative language worsening. Both intraoperative results and postsurgical transitory dysphasia support t...Continue Reading

References

Sep 30, 1977·Annals of the New York Academy of Sciences·T Rasmussen, B Milner
Oct 1, 1987·Brain : a Journal of Neurology·M SugishitaM Kawamura
Jun 1, 1965·Brain : a Journal of Neurology·N Geschwind
Jul 12, 1968·Science·N Geschwind, W Levitsky
Jan 1, 1984·Neuropsychologia·M D Winkelman, C C Glasson
Feb 1, 1996·Perceptual and Motor Skills·M Annett
Mar 1, 1996·Neuropsychologia·M T MenardS L Rauch
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·P DassonvilleJ Ashe
Jul 9, 1998·Brain and Language·K M KurowskiH Mathison
Apr 13, 1999·Lancet·R J WiseS K Scott
Jul 12, 2001·Neuroreport·H DuffauL Capelle
Jun 11, 2002·Nature Neuroscience·S KnechtA Pascual-Leone
Jul 12, 2002·Experimental Brain Research·Margret Hund-GeorgiadisD Yves von Cramon
Jul 24, 2002·Neurology·J P SzaflarskiT A Hammeke
Dec 19, 2002·Journal of Computer Assisted Tomography·Andrei I HolodnyWen-Ching Liu
Sep 4, 2003·Annals of Neurology·S Catrin BlankRichard J S Wise
Nov 19, 2003·The Behavioral and Brain Sciences·Michael C Corballis
Jan 24, 2004·Brain Research. Brain Research Reviews·Goulven Josse, Nathalie Tzourio-Mazoyer
Jan 27, 2004·NeuroImage·N Tzourio-MazoyerB Mazoyer
Apr 8, 2004·Brain and Language·Hermann Ackermann, Axel Riecker
Aug 12, 2004·Neuroreport·Masahiro AboKyozo Yonemoto
Dec 15, 2004·Annals of Neurology·Marco CataniDominic H ffytche
Dec 25, 2004·Physiological Reviews·Jean-François DémonetDominique Cardebat
Dec 29, 2004·Annals of Neurology·Alexander ThielWolf-Dieter Heiss
May 24, 2005·Epilepsy & Behavior : E&B·Rosette A JabbourGail L Risse
Jun 21, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·S Gil RoblesH Duffau
Jul 9, 2005·Current Opinion in Neurology·Stefan Klöppel, Christian Büchel
Jul 9, 2005·Current Opinion in Neurology·Cathy J Price, Jenny Crinion

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Citations

Apr 28, 2010·Journal of the International Neuropsychological Society : JINS·Michael E R NichollsGina M Grimshaw
Jul 17, 2009·Current Opinion in Oncology·Hugues Duffau
Jan 10, 2013·PloS One·Isabelle S HäberlingMichael C Corballis
Jan 18, 2011·Journal of Neurosurgery·Tejas Sankar, Andres M Lozano
Aug 3, 2010·Journal of Neurosurgery·Matthieu VassalHugues Duffau
Mar 27, 2012·Journal of Neurosurgery·Nader SanaiMitchel S Berger
Jan 21, 2014·Clinical Neurology and Neurosurgery·Elke De WittePeter Mariën
Oct 23, 2012·European Journal of Radiology·Nicolas Menjot de ChampfleurHugues Duffau
May 31, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Hugues Duffau
Jul 4, 2015·Journal of Neurosurgery·Guillaume HerbetHugues Duffau
Aug 19, 2015·Clinical Neuroradiology·K EggerH Urbach
Oct 31, 2009·NeuroImage·Timothy M EllmoreNitin Tandon
Nov 26, 2014·Journal of Neurosurgery·Edward F ChangMitchel S Berger
Sep 24, 2016·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Gianluca TrevisiHugues Duffau
Apr 7, 2018·PLoS Biology·Yuxing FangYanchao Bi
Jul 30, 2020·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Sanja BudisavljevicChiara Begliomini
Sep 13, 2020·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Clarissa Nunes VanacôrEberval Gadelha Figueiredo
Oct 20, 2018·Frontiers in Human Neuroscience·Louise O'Regan, Deborah J Serrien

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