Corticocortical connections between visual areas 17 and 18a of the rat studied in vitro: spatial and temporal organisation of functional synaptic responses

Experimental Brain Research
L G NowakJ Bullier

Abstract

Much is known about the anatomy of corticocortical connections, yet little is known concerning their physiology. In order to have access to the synaptic and temporal aspects of the activity elicited through corticocortical connections, we developed an in vitro approach on slices of rat visual cortex. We used extracellular recordings of field potentials combined with electrical stimulation to localise regions of areas 17 and 18a that are connected. We found that corticocortical connections between areas 17 and 18a can be preserved in 500 microm thick slices, with a focus of activity separated from the stimulating electrode by 1.5 mm to more than 3 mm. The potentials elicited in one area after stimulation of its neighbour displayed fast events, corresponding to action potentials, and slow events, corresponding to synaptic potentials. Intracellular recordings showed that the earliest synaptic responses consisted of monosynaptic excitatory potentials. Measurement of response latency showed that axons involved in both feedforward and feedback corticocortical connections are slowly conducting (0.3-0.8 m/s). Conduction velocity for antidromically activated cells was not significantly different for the two sets of connections. In an at...Continue Reading

Citations

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