Corticomotor responses to triple-pulse transcranial magnetic stimulation: Effects of interstimulus interval and stimulus intensity

Brain Stimulation
Paul SaccoG W Thickbroom

Abstract

Paired-pulse transcranial magnetic stimuli (TMS) applied to the motor cortex enhances motor-evoked potential (MEP) responses at specific interpulse intervals (IPIs), probably from summation of I-waves by the secondary TMS pulse. This study investigated the properties of I-wave periodicity by comparing double-pulse with triple-pulse TMS at varying IPIs and stimulus intensities. TMS was delivered to the optimal scalp position for the resting dominant first dorsal interosseous muscle at either active motor threshold (AMT) or AMT-5% stimulator output. In experiment 1, 4 conditions were tested, a double-pulse (D(1.5); IPI = 1.5 milliseconds), and triplets comprising D(1.5) with the addition of a third pulse at 1.5, 2.0, or 3.0 milliseconds (T(1.5)(1.5), T(1.5)(2.0), and T(1.5)(3.0), respectively). Each condition was tested at 2 stimulation intensities. In a second experiment, the same protocol was repeated with a single-pulse (giving an MEP equivalent to D(1.5)) replacing the first 2 pulses in each triplet. At AMT, MEP responses were significantly larger for T(1.5)(1.5) and T(1.5)(3.0) compared with D(1.5). Triple-pulse stimulation at AMT-5% resulted in no additional increase in MEP amplitude, or effect of IPI. Double-pulse TMS show...Continue Reading

References

Jun 1, 1976·The Journal of Physiology·E JankowskaR Tanaka
Aug 1, 1996·Electroencephalography and Clinical Neurophysiology·H TokimuraJ C Rothwell
May 12, 1998·The Journal of Physiology·R HanajimaI Kanazawa
Jan 5, 2002·The Journal of Physiology·Ritsuko HanajimaIchiro Kanazawa
Dec 6, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Gary W ThickbroomFrank L Mastaglia
Apr 3, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·V Di LazzaroJ C Rothwell
Nov 6, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Masashi HamadaYoshikazu Ugawa

❮ Previous
Next ❯

Citations

Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark S George, Gary Aston-Jones
May 4, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anthony P Atkinson, Ralph Adolphs
Feb 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Thomas E SchlaepferUNKNOWN WFSBP Task Force on Brain Stimulation
Mar 31, 2016·Neuroscience and Biobehavioral Reviews·D C W KloosterP Boon
Oct 28, 2010·Expert Review of Neurotherapeutics·Mark S George

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Related Papers

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Masashi HamadaYoshikazu Ugawa
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
V Di LazzaroJ C Rothwell
Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Adriana Bastos ConfortoAlain Kaelin-Lang
© 2021 Meta ULC. All rights reserved