Corticospinal output during muscular fatigue differs in multiple sclerosis patients compared to healthy controls

Multiple Sclerosis : Clinical and Laboratory Research
O ScheideggerK M Rösler

Abstract

In multiple sclerosis (MS), fatigue is a common and often disabling symptom. It has multiple causes with central motor fatigue playing an important role. The objective of this study was to analyse the central motor conduction changes in relation to muscle contraction force during muscle fatigue and recovery in MS patients compared to healthy controls. A total of 23 MS patients with fatigue and 13 healthy subjects were assessed during 2 minutes of fatiguing exercise of the abductor digiti minimi muscle of the hand and the subsequent 7 minutes of recovery. Central motor conduction was quantified by transcranial magnetic stimulation using the triple stimulation protocol and calculating a central conduction index (CCI). Force declined to 36% of the pre-exercise level (SD 16%; p < 0.01) in MS patients and to 44% (SD 9%, p < 0.01) in healthy subjects (group differences, not statistically significant). The decline of the CCI was significantly less marked in patients (-20%, SD 26%, p < 0.05) than in healthy subjects (-57%, SD 15%, p < 0.05; group differences, p < 0.05). The decline of force and CCI were not correlated in either group. During a fatiguing exercise, the decline in central motor conduction is significantly less pronounced ...Continue Reading

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Citations

Sep 9, 2015·Multiple Sclerosis and Related Disorders·Marion Simpson, Richard Macdonell
Jul 17, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·U Hofstadt-van OyP Oschmann
Sep 13, 2013·Neurorehabilitation and Neural Repair·Helen DawesHooshang Izadi
Apr 18, 2017·Neurorehabilitation and Neural Repair·Deborah SeverijnsPeter Feys
Aug 8, 2015·Journal of Neurologic Physical Therapy : JNPT·Brenda L DaviesMax J Kurz
Apr 27, 2019·Frontiers in Neurology·Laura Mordillo-MateosAntonio Oliviero

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