Corticospinal reorganization after spinal cord injury.

The Journal of Physiology
M Oudega, Monica A Perez

Abstract

The corticospinal tract (CST) is a major descending pathway contributing to the control of voluntary movement in mammals. During the last decades anatomical and electrophysiological studies have demonstrated significant reorganization in the CST after spinal cord injury (SCI) in animals and humans. In animal models of SCI, anatomical evidence showed corticospinal sprouts rostral and caudal to the lesion and their integration into intraspinal axonal circuits. Electrophysiological data suggested that indirect connections from the primary motor cortex to forelimb motoneurons, via brainstem nuclei and spinal cord interneurons, or direct connections from slow uninjured corticospinal axons, might contribute to the control of movement after a CST injury. In humans with SCI, post mortem spinal cord tissue revealed anatomical changes in the CST some of which were similar but others markedly different from those found in animal models of SCI. Human electrophysiological studies have provided ample evidence for corticospinal reorganization after SCI that may contribute to functional recovery. Together these studies have revealed a large plastic capacity of the CST after SCI. There is also a limited understanding of the relationship between...Continue Reading

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Citations

Dec 2, 2014·The Journal of Spinal Cord Medicine·Natalia Alexeeva, Blair Calancie
Mar 28, 2013·Annals of the New York Academy of Sciences·Marie-Claude Perreault, Joel C Glover
Apr 1, 2014·Brain and Behavior·Nimer Adeeb, Martin M Mortazavi
Aug 2, 2013·Acta Physiologica·C K ThomasI Zijdewind
Sep 2, 2014·Archives of Physical Medicine and Rehabilitation·Toshiki Tazoe, Monica A Perez
Jul 8, 2015·Brain Research Bulletin·Raffaele NardoneEugen Trinka
Nov 22, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michelle A Farrar, Matthew C Kiernan
Dec 3, 2014·Frontiers in Human Neuroscience·Inge ZijdewindChristine K Thomas
Dec 17, 2014·Experimental Brain Research·Victoria A StahlRandy D Trumbower
Jan 13, 2015·Journal of Motor Behavior·Jens Bo NielsenJakob Lorentzen
Mar 30, 2016·Annual Review of Neuroscience·Jens Bo Nielsen
Aug 4, 2016·The Journal of Physiology·Paolo Federico, Monica A Perez
Oct 6, 2016·Developmental Neurobiology·Quentin WelniarzEmmanuel Roze
May 27, 2017·Brain : a Journal of Neurology·Jinyi LongMonica A Perez
Mar 10, 2017·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·David M BrandmanLeigh R Hochberg
May 5, 2017·Journal of Neurophysiology·M A UrbinMonica A Perez
Oct 6, 2017·Clinical Medicine Insights. Case Reports·Yulia VainshenkerSvyatoslav Medvedev
Jun 21, 2018·The Journal of Physiology·Hang Jin JoMonica A Perez
Mar 5, 2019·Journal of Zhejiang University. Science. B·An-Kai XuHui-Min Tao
Jul 14, 2017·Journal of Neurophysiology·Recep A Ozdemir, Monica A Perez
Jan 24, 2019·Journal of Neurophysiology·Hang Jin Jo, Monica A Perez
Nov 13, 2019·The International Journal of Artificial Organs·Katarzyna LeszczyńskaPaweł Tabakow
May 8, 2020·Nature·Gunnar H D PoplawskiMark H Tuszynski
Sep 22, 2017·Journal of Neurophysiology·Yuming Lei, Monica A Perez
Nov 8, 2017·Physiotherapy Theory and Practice·Maryam Zoghi, Mary P Galea

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