Corticosteroid-binding globulin during inflammation and burn injury: nutritional modulation and clinical implications

Hormone Research
D R Garrel

Abstract

Corticosteroid-binding globulin (CBG) is the main carrier of glucocorticoids in mammals. Serum CBG shows little physiological variation with the exception of pregnancy. Experimental inflammation and burn injury decrease serum CBG in rats and while the mechanism of this effect is unknown, in vitro experiments suggest that interleukin-6 may be involved. In severely burned patients, we have found that CBG was markedly decreased within a few hours postinjury. This decrease lasted about 2 weeks and was accompanied by an increase in the free fraction of serum cortisol. In addition, serum CBG responded to dietary manipulation in these patients, with low fat feeding resulting in higher serum CBG concentrations and lower serum-free cortisol values. This feeding suggests that during severe stress, CBG may be important in regulating the amount of cortisol reaching target tissues such as the immune system and wounds.

Citations

Dec 21, 2002·Clinical Biochemistry·Michael VogeserReinhart Zachoval
Jan 22, 2002·Journal of Psychosomatic Research·Paul H Black, Lisa D Garbutt
Nov 5, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M D'EliaJ Bernier
Apr 16, 2004·The New England Journal of Medicine·Amir H HamrahianBaha M Arafah
Oct 21, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John C Marshall
Sep 26, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Tina L PalmieriDavid G Greenhalgh
Aug 18, 2004·Critical Care : the Official Journal of the Critical Care Forum·Hélène PrigentDjillali Annane
Oct 13, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Robin MihrshahiSinan O Ali
Oct 19, 2006·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S HosoyaL O B Afonso
Aug 25, 2015·Animal : an International Journal of Animal Bioscience·C LarzulP Mormede
Jun 28, 2012·Stress : the International Journal on the Biology of Stress·E M PollI Kreitschmann-Andermahr
Jan 22, 2002·Best Practice & Research. Clinical Endocrinology & Metabolism·I Vermes, A Beishuizen
Jan 18, 2005·Pharmacology, Biochemistry, and Behavior·Bruce NockMichele Wich
Apr 27, 2016·The Journal of Endocrinology·Geoffrey L Hammond
Sep 14, 2000·QJM : Monthly Journal of the Association of Physicians·F J KaplanS G Soule
Jul 26, 2000·Medicine and Science in Sports and Exercise·D G Rowbottom, K J Green

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.