Corticosteroid-binding globulin is a biomarker of inflammation onset and severity in female rats

The Journal of Endocrinology
Lesley A HillGeoffrey L Hammond

Abstract

Plasma corticosteroid-binding globulin (CBG) plays a critical role in regulating glucocorticoid bioavailability and is an acute phase 'negative' protein during inflammation. In an adjuvant-induced arthritis model, plasma CBG levels decrease in rats that develop severe inflammation, and we have now determined when and how these reductions in CBG occur. After administering complete Freund's adjuvant or saline intra-dermally at the tail base, blood samples were taken periodically for 16days. In adjuvant-treated rats, decreases in plasma CBG levels matched the severity of inflammation, and decreases were observed 4days before any clinical signs of inflammation. Decreases in CBG levels coincided with an ~5kDa reduction in its apparent size, consistent with proteolytic cleavage, and cleaved CBG lacked steroid-binding activity. At the termination of the experimental period, hepatic Cbg mRNA levels were decreased in rats with severe inflammation. While plasma TNF-α increased in all adjuvant-treated rats, increases in Il-4, IL-6, IL-10, IL-13 and IFN-γ were only observed in rats with cleaved CBG. Rats with cleaved CBG also exhibited increased spleen weights, and strong negative correlations were observed among CBG, IL-6 and spleen weigh...Continue Reading

References

Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·G L HammondD A Underhill
Jul 1, 1990·The Journal of Clinical Endocrinology and Metabolism·G L HammondW J Sibbald
Jul 31, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·G L Hammond, P L Lähteenmäki
Jul 1, 1996·Steroids·A A TinnikovS G Sidelnikov
Jan 1, 1996·Alimentary Pharmacology & Therapeutics·R Brattsand, M Linden
Mar 22, 2001·The New England Journal of Medicine·E H Choy, G S Panayi
Jul 28, 2001·European Journal of Gastroenterology & Hepatology·G Ramadori, T Armbrust
May 20, 2003·Immunological Reviews·Hans-Uwe Simon
Dec 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·Michele D'EliaJacques Bernier
Nov 3, 2005·The Journal of Clinical Endocrinology and Metabolism·J T HoD J Torpy
Sep 19, 2006·Molecular and Cellular Biology·Helle Heibroch PetersenThomas E Willnow
Jan 1, 1993·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·D R GarrelG L Hammond
May 24, 2008·Anesthesia and Analgesia·Stepani BendelUNKNOWN Finnsepsis Study Group
Feb 5, 2009·Autoimmunity Reviews·J E FonsecaE Choy
Aug 1, 2009·Molecular and Cellular Endocrinology·Hai-Yan LinGeoffrey L Hammond
Aug 1, 2009·Molecular and Cellular Endocrinology·Lucia GagliardiDavid J Torpy
Dec 14, 2011·Brain, Behavior, and Immunity·Xingqi ZhangJoanne Weinberg
Aug 15, 2012·Nature Reviews. Endocrinology·Ilias PerogamvrosPeter J Trainer
Jan 16, 2014·Molecular and Cellular Endocrinology·John G Lewis, Peter A Elder
Oct 17, 2014·The Journal of Clinical Endocrinology and Metabolism·Marc SimardGeoffrey L Hammond

❮ Previous
Next ❯

Citations

Feb 9, 2017·Stress : the International Journal on the Biology of Stress·Marni Anne NenkeDavid James Torpy
Dec 24, 2017·Journal of Molecular Endocrinology·Marc SimardGeoffrey L Hammond
Nov 20, 2018·The Journal of Endocrinology·Lesley A HillGeoffrey L Hammond
Jan 15, 2020·PloS One·Annelyn Torres-ReverónCaroline B Appleyard
Jul 31, 2018·Expert Review of Endocrinology & Metabolism·Emily J MeyerDavid J Torpy
Mar 22, 2019·International Journal of Molecular Sciences·Stephenie D ProkopecPaul C Boutros

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.