Corticosteroid-binding globulin is a biomarker of inflammation onset and severity in female rats

The Journal of Endocrinology
Lesley A HillGeoffrey L Hammond


Plasma corticosteroid-binding globulin (CBG) plays a critical role in regulating glucocorticoid bioavailability and is an acute phase 'negative' protein during inflammation. In an adjuvant-induced arthritis model, plasma CBG levels decrease in rats that develop severe inflammation, and we have now determined when and how these reductions in CBG occur. After administering complete Freund's adjuvant or saline intra-dermally at the tail base, blood samples were taken periodically for 16days. In adjuvant-treated rats, decreases in plasma CBG levels matched the severity of inflammation, and decreases were observed 4days before any clinical signs of inflammation. Decreases in CBG levels coincided with an ~5kDa reduction in its apparent size, consistent with proteolytic cleavage, and cleaved CBG lacked steroid-binding activity. At the termination of the experimental period, hepatic Cbg mRNA levels were decreased in rats with severe inflammation. While plasma TNF-α increased in all adjuvant-treated rats, increases in Il-4, IL-6, IL-10, IL-13 and IFN-γ were only observed in rats with cleaved CBG. Rats with cleaved CBG also exhibited increased spleen weights, and strong negative correlations were observed among CBG, IL-6 and spleen weigh...Continue Reading


Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·G L HammondD A Underhill
Jul 1, 1990·The Journal of Clinical Endocrinology and Metabolism·G L HammondW J Sibbald
Jul 31, 1983·Clinica Chimica Acta; International Journal of Clinical Chemistry·G L Hammond, P L Lähteenmäki
Jul 1, 1996·Steroids·A A TinnikovS G Sidelnikov
Jan 1, 1996·Alimentary Pharmacology & Therapeutics·R Brattsand, M Linden
Mar 22, 2001·The New England Journal of Medicine·E H Choy, G S Panayi
Jul 28, 2001·European Journal of Gastroenterology & Hepatology·G Ramadori, T Armbrust
May 20, 2003·Immunological Reviews·Hans-Uwe Simon
Dec 16, 2004·American Journal of Physiology. Endocrinology and Metabolism·Michele D'EliaJacques Bernier
Nov 3, 2005·The Journal of Clinical Endocrinology and Metabolism·J T HoD J Torpy
Sep 19, 2006·Molecular and Cellular Biology·Helle Heibroch PetersenThomas E Willnow
Jan 1, 1993·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·D R GarrelG L Hammond
May 24, 2008·Anesthesia and Analgesia·Stepani BendelUNKNOWN Finnsepsis Study Group
Feb 5, 2009·Autoimmunity Reviews·J E FonsecaE Choy
Aug 1, 2009·Molecular and Cellular Endocrinology·Hai-Yan LinGeoffrey L Hammond
Aug 1, 2009·Molecular and Cellular Endocrinology·Lucia GagliardiDavid J Torpy
Dec 14, 2011·Brain, Behavior, and Immunity·Xingqi ZhangJoanne Weinberg
Aug 15, 2012·Nature Reviews. Endocrinology·Ilias PerogamvrosPeter J Trainer
Jan 16, 2014·Molecular and Cellular Endocrinology·John G Lewis, Peter A Elder
Oct 17, 2014·The Journal of Clinical Endocrinology and Metabolism·Marc SimardGeoffrey L Hammond

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Feb 9, 2017·Stress : the International Journal on the Biology of Stress·Marni Anne NenkeDavid James Torpy
Dec 24, 2017·Journal of Molecular Endocrinology·Marc SimardGeoffrey L Hammond
Nov 20, 2018·The Journal of Endocrinology·Lesley A HillGeoffrey L Hammond
Jan 15, 2020·PloS One·Annelyn Torres-ReverónCaroline B Appleyard
Jul 31, 2018·Expert Review of Endocrinology & Metabolism·Emily J MeyerDavid J Torpy
Mar 22, 2019·International Journal of Molecular Sciences·Stephenie D ProkopecPaul C Boutros

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