PMID: 3773513Sep 1, 1986Paper

Corticosteroid binding in plasma of Xenopus laevis. Modifications during metamorphosis and growth

Journal of Steroid Biochemistry
G Jolivet-Jaudet, J Leloup-Hâtey

Abstract

The binding of corticosteroids has been studied by equilibrium dialysis at 4 degrees C and electrophoresis on polyacrylamide gel. Aldosterone was not bound specifically. Large amounts of corticosterone (B) were bound. A high affinity (Ka = 2.8 X 10(8) M-1) low capacity (70.1 nM) component was found in tadpoles. Its affinity and its electrophoretic mobility were not significantly modified during metamorphosis and growth until adult. It differs from mammalian CBG with respect to affinity, electrophoretic mobility and specificity. During growth, the capacity of the high affinity component increased significantly (173 nM in adults) and a low affinity (Ka = 2.0 X 10(5) M-1) high capacity (18.26 microM) component was detected. This last component has the same electrophoretic mobility as bovine serum albumin. These modifications can be related to the large increase in the level of plasma proteins (especially albumins). The concentrations of bound and free B deduced from our data indicate that in tadpoles the increase in the total concentration in the climax is not a good reflection of modifications of these two fractions since the change of free B is larger than that of bound B. This information is an important consideration in interp...Continue Reading

References

Jan 1, 1970·Acta Endocrinologica. Supplementum·U Westphal
Nov 15, 1971·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·R C Feldhoff
Jul 1, 1981·General and Comparative Endocrinology·R C Jaffe
Nov 1, 1983·General and Comparative Endocrinology·E C KrugC S Nicoll
Oct 1, 1984·General and Comparative Endocrinology·G Jolivet Jaudet, J Leloup Hatey
Jan 1, 1984·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·G Jolivet-Jaudet, J Leloup-Hatey
Jan 1, 1983·General and Comparative Endocrinology·F L MooreJ Wingfield
Jan 1, 1984·General and Comparative Endocrinology·G Jolivet-JaudetS Ishii
Feb 1, 1959·The Journal of Clinical Investigation·W R SLAUNWHITE, A A SANDBERG

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Citations

Jan 23, 1999·Immunological Reviews·L A Rollins-Smith
Feb 16, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Sandra E HernándezAdrian J Bradley
Mar 1, 1990·The American Journal of Physiology·W M GroganC O Watlington

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