Corticosteroid effect on granulopoiesis in mice after cyclophosphamide

The Journal of Clinical Investigation
R A Joyce, P A Chervenick

Abstract

Corticosteroids cause an enhanced return of granulopoiesis as measured by in vitro growth of granulocytic progenitor cells (CFU-C) in mice treated with cyclophosphamide. After methylprednisolone and cyclophosphamide, a greater than threefold increase in marrow CFU-C was measured on day 4 compared to mice given cyclophosphamide alone (29,700+/-200 vs. 8,400+/-700/humerus). The accelerated return of marrow CFU-C was observed with cyclophosphamide in doses of 200 and 450 mg/kg and methylprednisolone, 2-20 mg/kg, with no significant differences using >5 mg/kg, and was detected when dexamethasone was used in place of methylprednisolone. This effect was accompanied by similarly enhanced splenic granulopoiesis as measured by CFU-C concentration. Levels of colony stimulating activity did not differ in mice given methylprednisolone and cyclophosphamide or cyclophosphamide alone. Corticosteroids appear to enhance the return of CFU-C by altering the proliferative state of granulocytic progenitor cells. CFU-C survival to in vitro (3)HTdR suicide increased from 72+/-4% on day 1 after cyclophosphamide to 90+/-6% in animals given both cyclophosphamide and methylprednisolone. Increased survival after (3)HTdR suicide was also observed when meth...Continue Reading

References

May 1, 1976·Journal of Steroid Biochemistry·J M TredgerD V Parke
Jun 1, 1966·The Australian Journal of Experimental Biology and Medical Science·T R Bradley, D Metcalf
Oct 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·D Metcalf
May 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·N N IscoveE A McCulloch
Aug 1, 1970·Journal of Cellular Physiology·B L Pike, W A Robinson
Dec 1, 1965·Journal of Cellular Physiology·D H Pluznik, L Sachs
Mar 16, 2005·Seminars in Hematology·Mohamad A Hussein

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Citations

Dec 1, 1988·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J W van 't WoutR van Furth
Jan 1, 1979·Vox Sanguinis·A GórskiT Orłowski
Sep 1, 1985·The Journal of Clinical Investigation·B H BjornsonL Rose
Feb 19, 2009·Veterinary and Comparative Oncology·J L IntileJ J Wakshlag
Sep 1, 1987·Zentralblatt für Veterinärmedizin. Reihe A·W G RudolphF P Donoso
Dec 1, 1983·International Journal of Cell Cloning·J M HealJ Nusbacher
Oct 7, 2004·Cancer·Karsten MünstedtRichard von Georgi
Jul 1, 1983·Scandinavian Journal of Haematology·R D BarrR A Milner
Feb 1, 1980·Infection and Immunity·S A Moser, J E Domer

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