PMID: 489465Jun 1, 1979Paper

Corticosteroid-induced mandibular growth retardation and palatal malformation in the ICR mouse fetus

Journal of Anatomy
M Silbermann, S Levitan

Abstract

Pregnant ICR mice were treated with triamcinolone hexacetonide at various stages of gestation. The mandibular ramus and its condylar cartilage were studied histologically in both viable and non-viable offspring. In addition, measurements were made of the overall height of the posterior vertical dimension of the mandible and of condylar height and width. Significant changes were noted in these parameters. Concomitantly, marked changes were observed in the various zones of the condylar cartilage. A very high incidence of cleft palate was noted in newborn and stillborn mice previously treated with triamcinolone. A possible correlation between mandibular growth retardation and palatal clefting is discussed.

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Citations

Jul 9, 2005·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Johannes SchubertMarkus Berginski
Apr 1, 1990·Scandinavian Journal of Gastroenterology·A R ZlatkinaL V Chervonnaya

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