Corticosteroid nasal irrigations after endoscopic sinus surgery in the management of chronic rhinosinusitis

International Forum of Allergy & Rhinology
Kornkiat SnidvongsRichard J Harvey

Abstract

Inflammatory dysfunction is considered an important part of chronic rhinosinusitis (CRS). Corticosteroid therapy has been widely used in CRS. Effective topical delivery has been previously problematic. The post-endoscopic sinus surgery (ESS) corridor is essential for adequate topical drug access. Devices delivering large volume with positive pressure allow better distribution to sinus mucosa. The objective of this study is to evaluate the efficacy of postoperative topical sinonasal steroid irrigations for CRS. Patients with CRS undergoing ESS after failing previous medical therapy were recruited. Structured histopathology including markers of eosinophilia was performed. After surgery, patients received either budesonide 1 mg or betamethasone 1 mg delivered in a 240-mL squeeze bottle daily. Outcomes of the symptom score, Sino-Nasal Outcome Test 22 (SNOT-22) score, and endoscopy score were recorded. A total of 111 patients (mean 50.1 ± 13.5 standard deviation [SD] years, 40.5% female) were included. Mean follow-up was 55.5 ± 33.9 weeks. Baseline and posttreatment symptom scores (2.6 ± 1.1 vs 1.2 ± 1.0), SNOT-22 scores (2.2 ± 1.1 vs 1.0 ± 0.8), and endoscopy scores (6.7 ± 3.0 vs 2.5 ± 2.0) revealed significant improvement (all, p ...Continue Reading

References

Sep 1, 1992·The Journal of Laryngology and Otology·M D FlynnJ E Tooke
Mar 1, 1988·The Journal of Laryngology and Otology·D J Stevens
Feb 24, 1998·The Laryngoscope·B A SeniorD Lanza
Sep 11, 1998·BMJ : British Medical Journal·C A FindlayM D Donaldson
Jun 22, 2001·Journal of the Royal Society of Medicine·G GillP Weston
Feb 14, 2004·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kyosuke FurukidoKoji Yajin
Dec 22, 2006·American Journal of Rhinology·John M DelGaudio, Sarah K Wise
Aug 30, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Stephanie A JoeJie Huang
Oct 29, 2008·American Journal of Rhinology·Kornkiat SnidvongsPuangmali Praweswararat
Oct 2, 2009·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·C HopkinsJ P Browne
Nov 3, 2009·Immunology and Allergy Clinics of North America·Joaquim MullolIsam Alobid
Nov 17, 2009·Otolaryngologic Clinics of North America·Richard J Harvey, Rodney J Schlosser
Nov 17, 2009·The Journal of Allergy and Clinical Immunology·John W SteinkeLarry C Borish
Nov 26, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Richard J HarveyRodney J Schlosser
Jan 26, 2010·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Zachary M SolerTimothy L Smith
Aug 26, 2010·The Annals of Otology, Rhinology, and Laryngology·Fuat TosunAbdullah Durmaz

❮ Previous
Next ❯

Citations

Feb 5, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Kejun ZuoHuabin Li
Oct 16, 2015·International Forum of Allergy & Rhinology·Rodney J SchlosserZachary M Soler
Oct 4, 2013·Expert Opinion on Drug Delivery·Jivianne T Lee, Joseph K Han
Feb 20, 2016·International Forum of Allergy & Rhinology·Richard R OrlandiDavid W Kennedy
Jan 12, 2016·International Forum of Allergy & Rhinology·Kristine A SmithLuke Rudmik
Dec 15, 2015·Current Opinion in Allergy and Clinical Immunology·Hongfei LouLuo Zhang
Jun 27, 2013·International Forum of Allergy & Rhinology·Peta-Lee SacksRichard J Harvey
Oct 10, 2012·International Forum of Allergy & Rhinology·Luke RudmikTimothy L Smith
Apr 5, 2013·The Laryngoscope·Kornkiat SnidvongsRichard J Harvey
Oct 16, 2012·International Forum of Allergy & Rhinology·David W Kennedy
Jun 19, 2013·International Forum of Allergy & Rhinology·David W JangStilianos E Kountakis
Jul 24, 2013·The Laryngoscope·Rachel GogginSarah Vreugde
Mar 19, 2016·International Forum of Allergy & Rhinology·Timothy Q DoRichard J Harvey
Nov 29, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Rohit D DivekarHirohito Kita
Oct 4, 2015·Brazilian Journal of Otorhinolaryngology·Eduardo Macoto KosugiJosé Arruda Mendes Neto
Apr 25, 2015·International Forum of Allergy & Rhinology·Adam S DeCondeTimothy L Smith
Dec 17, 2014·Current Opinion in Otolaryngology & Head and Neck Surgery·Christopher F Thompson, David B Conley
Jul 22, 2016·Clinical and Experimental Otorhinolaryngology·Tae Wook KangJin Hyeok Jeong
Aug 9, 2016·Expert Opinion on Drug Delivery·Rickul Varshney, Jivianne T Lee
Jul 18, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Neil BhattacharyyaRichard M Rosenfeld
Dec 18, 2013·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kornkiat SnidvongsRichard J Harvey
Oct 21, 2017·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·H Y YoonS H Hwang
Oct 24, 2017·Current Opinion in Otolaryngology & Head and Neck Surgery·Raewyn G Campbell
Nov 3, 2017·Current Opinion in Otolaryngology & Head and Neck Surgery·Carolyn A Orgain, Richard J Harvey
Jun 1, 2018·International Forum of Allergy & Rhinology·Amar MiglaniDevyani Lal
Nov 28, 2013·American Journal of Rhinology & Allergy·Rodney J Schlosser, Zachary M Soler
Feb 25, 2017·American Journal of Rhinology & Allergy·Dan YanivEitan Yaniv
Apr 11, 2014·American Journal of Rhinology & Allergy·Hae W JoRichard J Harvey
Apr 9, 2013·American Journal of Rhinology & Allergy·Christopher F ThompsonJeffrey D Suh
Jul 12, 2018·Current Allergy and Asthma Reports·Wirach ChitsuthipakornKornkiat Snidvongs
Oct 3, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Marc-Henri AsmarMartin Desrosiers
Jan 25, 2019·American Journal of Rhinology & Allergy·Zachary H GriggsJohn R Craig
Feb 23, 2019·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Zi-Zhen HuangGe-Hua Zhang
Sep 13, 2017·The Journal of Laryngology and Otology·B DawsonD Robinson
Jan 2, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Alice Huang, Satish Govindaraj
Jul 26, 2019·International Forum of Allergy & Rhinology·Revadi GovindarajuAlkis James Psaltis
Jul 2, 2019·International Forum of Allergy & Rhinology·Jessica W GraysonRichard J Harvey
Jan 17, 2020·International Forum of Allergy & Rhinology·Qasim HusainBenjamin S Bleier
Feb 29, 2020·International Forum of Allergy & Rhinology·Jessica W GraysonRichard J Harvey
Apr 4, 2020·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·Tobial McHughDoron D Sommer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Forum of Allergy & Rhinology
Jonathan Liang, E Bradley Strong
BMJ : British Medical Journal
G Gallagher, I S Mackay
International Forum of Allergy & Rhinology
David W JangStilianos E Kountakis
International Forum of Allergy & Rhinology
Kristin A SeiberlingChristopher A Church
© 2021 Meta ULC. All rights reserved